King, Carolyn
Biography
Since 2015 ETH Zürich (Basel, Switzerland)
Postdoctoral Fellow
Department of Biosystems Science and Engineering
Cell Systems Dynamics Research Group (Prof. Dr. Timm Schroeder)
2013-present University Hospital Basel, DBM, (Basel Switzerland)
SNSF Ambizione Fellow
Project: Origins of CD4 T cell heterogeneity during infection
2008-2012 DBM, University Hospital Basel (Basel, Switzerland)
Postdoctoral Fellow, Transplantation Immunology (Prof. Dr. Ed Palmer)
Project: Role of TCR affinity during infection and tolerance
2007-2008 University of Pennsylvania (Philadelphia, USA)
Postdoctoral Fellow (Dr. Yongwon Choi)
2001-2006 University of Pennsylvania (Philadelphia, USA)
Philosophiae Doctor (PhD)
Thesis: “TRAF6 and T cell tolerance” (Dr. Yongwon Choi)
2001 California Department of Health Services/Makere University, Kampala, Uganda
Research associate
1999-2001 Gladstone Institute of Virology and Immunology (San Francisco, USA)
Research associate
Project: Mother to fetus lymphocyte trafficking (Dr. Karen Beckerman, Dr. Mike McCune)
1993-1997 Duke University (North Carolina, USA)
Fellowships & Awards
Since 2013 SNSF Ambizione Fellowship
2015 Novartis Foundation for Medical-Biological Research
2014 University of Basel Forschungsfond
2013 Swiss Transplantation Society Award
2009-2012 Human Frontiers Science Program, Long term fellowship
2008-2009 EMBO, Long term fellowship
2006 Finalist, Judy S. Finkelstein Symposium in Immunology Research
2006 Ray Owen Young Investigator Award, Midwinter Conference
Publications
Keck S, Schmaler M, Wyss L, Oberle S, Huseby ES, Zehn D, King CG*. (2014)
Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation.
PNAS, 111: 14852-14857
Stepanek O, Prabhakar AS, Osswald C, King CG, Bulek A, Naeher D, Beaufils-Hugot M, Abanto M, Galati V, Hausmann B, Lang R, Cole DK, Huseby E, Sewell AK, Chakraborty AK, Palmer E. (2014)
Coreceptor-mediated Lck delivery to the TCR sets the antigen swell-time threshold for central tolerance.
Cell, 159: 333-345
King CG*, Koehli S, Hausmann B, Schmaler M, Zehn D, Palmer E. (2012)
Induction of tissue pathology driven by asymmetric T cell division.
Immunity, 37: 709-720.
Highlighted in Nature Reviews Immunology, December 2012.
Zehn D, King CG, Bevan MJ, Palmer E. (2012)
TCR signaling requirements for activating T cells and generating memory.
Cell Mol Life Sci., 69: 1565-1575
King CG, Kobayashi T, Kim T, Hickman SP, Turka LA, Choi Y. (2008)
Cutting edge: requirement for TRAF6 in T Cell Anergy Induction.
Cutting Edge JI., 180: 34-38
King CG, Kobayashi T, Cejas P, Kim T, Yoon K, Kim GK, Chiffoleau E, Hickman SP, Walsh PT, Turka LA, Choi Y. (2006)
TRAF6 is a T Cell Intrinsic Negative Regulator Required for the Maintenance of Immune Homeostasis.
Nature Medicine, 12: 1088-1092
Kobayashi T, Walsh PT, Walsh MC, Speirs KM, Chiffoleau E, King CG, Hancock WW, Caamano JH, Hunter CA, Scott P, Turka LA, Choi Y. (2003)
TRAF6 is a critical factor for dendritic cell maturation and development.
Immunity, 19: 353-363
Chiffoleau E, Kobayashi T, Walsh MC, King CG, Walsh PT, Hancock WW, Choi Y, Turka LA. (2003)
TNF receptor-associated factor 6 deficiency during hematopoiesis induces Th2-polarized inflammatory disease.
J. Immunol, 171: 5751-5759
*corresponding author