Understanding gene regulation in bacteria to develop new biotechnological solutions
D-BSSE researchers shed new light on gene regulation and expression in bacteria. Applying a novel method for high-throughput sequence-function mapping, Simon Höllerer and Markus Jeschek from the Bioprocess lab characterised over 1.2 million mRNA variants in Escherichia coli. Their key findings: a common assumption on how gene expression works has been disproved. Additionally, the researchers found experimental evidence for a postulated mechanism in gene expression.
Find original paper in Nucleid Acids Research:
Höllerer, S and M Jeschek (2023) external pageUltradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript. Nucleic Acids Research, Volume 51, Issue 5, 21 March 2023, Pages 2377-2396,
external pagehttps://doi.org/10.1093/nar/gkad040
Learn about the Bioprocess lab led by Sven Panke.