Multi-Locus Mapping of Genetic Heterogeneity (FAIS)

Enlarged view: Cover of the Bioinformatics journal

Felipe Llinares-López, Dominik G. Grimm, Dean A. Bodenham, Udo Gieraths, Mahito Sugiyama, Beth Rowan, Karsten Borgwardt

Genome-wide detection of intervals of genetic heterogeneity associated with complex traits

Summary

We present an algorithm for discovering contiguous sets of SNPs in a genome that are associated to a phenotype of interest under a model of genetic heterogeneity. The algorithm can search any contiguous set of SNPs in the genome and still properly correct for mutiple testing, while retaining statistical power.

Code

The code is available in our GitHub repository external page here.

Publication

Genome-wide detection of intervals of genetic heterogeneity associated with complex traits

Felipe Llinares-López, Dominik G. Grimm, Dean A. Bodenham, Udo Gieraths, Mahito Sugiyama, Beth Rowan and Karsten Borgwardt
ISMB 2015 and Bioinformatics 2015, 31 (12): i240-i249
external page Online | ETH Research Collection | Project page | external page GitHub

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