Journal Articles
2024
K. Kasuba, A. Buccino, J. Bartram, B. Gaub, F. Fauser, S. Ronchi, S. Kumar, S. Geissler, M. Nava, A. Hierlemann, D. Müller, "Mechanical stimulation and electrophysiological monitoring at subcellular resolution reveals differential mechanosensation of neurons within networks", Nature Nanotechnology 2024, 19, p. 825-833 (DOI: 10.1038/s41565-024-01609-1). external page Online
A. Kurmashev, J. Boos, B. Laventie, L. Swart, R. Sütterlin, T. Junne, U. Jenal, A. Hierlemann, "Transwell-based microfluidic platform for high-resolution imaging of airway tissues", Adv. Mater. Technol. 2024, Article 2400326 (DOI: 10.1002/admt.202400326). external page Online
P. Wang, E. Wu, H. Ulusan, E. Zhao, A. Phillips, A. Kling, M. Hays, P. Vasireddy, S. Madugula, R. Vilkhu, A. Hierlemann, G. Hong, E.J. Chichilnisky, and N. Melosh, "Direct-print 3D electrodes for large-scale, high-density, and customizable neural interfaces", Advanced Science 2024, Article 2408602 (DOI: 10.1002/advs.202408602). external page Online
T. van der Molen, M. Lim, J. Bartram, Z. Cheng, A. Robbins, D. Parks, L. Petzold, A. Hierlemann, D. Haussler, P. Hansma, K. Tovar, K. Kosik, "RT-Sort: An action potential propagation-based algorithm for real time spike detection and sorting with millisecond latencies", PLOS One 2024, 19(12), Article e0312438 (DOI: 10.1371/journal.pone.0312438). external page Online
C. Sampaio, J. Boos, J. Goldowsky, N. Schmid, M. Blache, T. Heinemann, C. Netsch, F. Luongo, S. Boder-Pasche, G. Weder, A. Pueyo Moliner, R. Samsom, A. Marsee, K. Schneeberger, A. Mirsaidi, B. Spee, T. Valentin, A. Hierlemann, V. Revol, "High-throughput platform for label-free sorting of 3D spheroids using deep learning", Frontiers in Bioengineering and Biotechnology 2024, Vol. 12, Article 1432737 (DOI: 10.3389/fbioe.2024.1432737). external page Online
J. Lee, E. Duperrex, I. El-Battrawy, A. Saguner, F. Duru, V. Emmenegger, L. Cyganek, A. Hierlemann, H. Ulusan, "CardioMEA: comprehensive data analysis platform for studying cardiac diseases and drug responses", Frontiers in Physiology 2024, 15 (DOI: 10.3389/fphys.2024.1472126). external page Online
M. Cartiglia, F. Costa, S. Narayanan, C. H. Bui,H. Ulusan, N. Risi, G. Haessig, A. Hierlemann, F. Cardes, G. Indiveri, "A 4096 channel event-based multielectrode array with asynchronous outputs compatible with neuromorphic processors", Nature Communications 2024, Vol. 15, Article 7163 (DOI: 10.1038/s41467-024-50783-2). external page Online
C. Donner, J. Bartram, P. Hornauer, T. Kim, D. Roqueiro, A. Hierlemann, G. Obozinski, M. Schröter, "Ensemble learning and ground-truth validation of synaptic connectivity inferred from spike trains", PLOS Computational Biology 2024, 20 (4), Article e1011964. Online
O. Nguyen, P. Misun, A. Hierlemann, C. Lohasz, "A versatile intestine-on-chip system for deciphering the immunopathogenesis of inflammatory bowel disease", Advanced Healthcare Materials 2024, 13, Article 2302454 (DOI: 10.1002/adhm.202302454). external page Online
M. Hruska-Plochan, V. Wiersma, K. Betz, I. Mallona, S. Ronchi, Z. Maniecka, E. Hock, E. Tantardini, F. Laferriere, S. Sahadevan, V. Hoop, I. Delvendahl, M. Pérez-Berlanga, B. Gatta, M. Panatta, A. van der Bourg, D. Bohaciakova, P. Sharma, L. De Vos, K. Frontzek, A. Aguzzi,T. Lashley, M. Robinson, T. Karayannis, M. Müller, A. Hierlemann & M. Polymenidou, "A model of human neural networks reveals NPTX2 pathology in ALS and FTLD", Nature 2024, 626, p. 1073–1083 (DOI: 10.1038/s41586-024-07042-7). Online
A. Buccino, T. Damart, J. Bartram, D. Mandge, X. Xue, M. Zbili, T. Gänswein, A. Jaquier, V. Emmenegger, H. Markram, A. Hierlemann, W. Van Geit, "A multimodal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays", Neural Computation 2024, 36, p. 1286-1331 (DOI: 10.1162/neco_a_01672). external page Online
J. Sollier, M. Basler, P. Broz, P. Dittrich, K. Drescher, A. Egli, A. Harms, A. Hierlemann, S. Hiller, C. King, J. McKinney, J. Moran-Gilad, R. Neher, M. Page, S. Panke, A. Persat, P. Picotti, K. Rentsch, P. Rivera-Fuentes, U. Sauer, D. Stolz, S. Tschudin-Sutter, C. van Delden, E. van Nimwegen, J-W. Veening, M. Zampieri, A. Zinkernagel, N. Khanna, D. Bumann, U. Jenal, C. Dehio, "Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions", Nature Microbiology 2024, 9, p. 1–3 (DOI: 10.1038/s41564-023-01566-w). external page Online
2023
P. Hornauer, G. Prack, N. Anastasi, S. Ronchi, T. Kim, C. Donner, M. Fiscella, K. Borgwardt, V. Taylor, R. Jagasia, D. Roqueiro, A. Hierlemann, M. Schröter, "DeePhys: A machine learning–assisted platform for electrophysiological phenotyping of human neuronal networks", Stem Cell Reports 2023, 19 (2), p. 285-298 (DOI: 10.1016/j.stemcr.2023.12.008). external page Online
E. T. Zhao, J. M. Hull, N. M. Hemed, H. Uluşan, J. Bartram, A. Zhang, P. Wang, A. Pham, S. Ronchi, J. R. Huguenard, A. Hierlemann, and N. A. Melosh, "A CMOS-based highly scalable flexible neural electrode interface", Science Advances 2023, 9, Article: eadf9524 (DOI:10.1126/sciadv.adf9524). external page Online
J. Bartram, F. Franke, S. Kumar, A. Buccino, X. Xue, T. Gänswein, M. Schröter, T. Kim, K. Kasuba, A. Hierlemann, "Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking", eLife 2023, Article 12:RP86820 (DOI: 10.7554/eLife.86820.2). external page Online
W. Wei, F. Cardes, A. Hierlemann, M. Modena, "3D in vitro blood-brain-barrier model for investigating barrier insults", Advanced Science 2023, Article 2205752 (DOI: 10.1002/advs.202205752). external page Online
M. Gazorpak, K.M. Hugentobler, D. Paul, P.-L. Germain, M. Kretschmer, I. Ivanova, S. Frei, K. Mathis, R. Rudolf, S. Mompart Barrenechea, V. Fischer, X. Xue, A. L. Ptaszek, J. Holzinger, M. Privitera, A. Hierlemann, O. C. Meijer, R. Konrat, E. M. Carreira, J. Bohacek and K. Gapp, "Harnessing PROTAC technology to combat stress hormone receptor activation", Nature Communications 2023, 14, p. 8177 (DOI: 10.1038/s41467-023-44031-2). external page Online
F. Cardes, E. Azizi, A. Hierlemann, "A time-domain readout technique for neural interfaces based on VCO-timestamping", IEEE Transactions on Biomedical Circuits and Systems 2023, 17 (3), p. 574-584 (DOI: 10.1109/TBCAS.2023.3274834). external page Online
F. Gökçe, A. Kaestli, C. Lohasz, M. de Geus, H.-M. Kaltenbach, K. Renggli, B. Bornhauser, A. Hierlemann, M. Modena, "Microphysiological drug-testing platform for identifying responses to prodrug treatment in primary leukemia", Advanced Healthcare Materials 2023, Article 2202506 (DOI: 10.1002/adhm.202202506). external page Online
2022
T. Kim, D. Chen, P. Hornauer, V. Emmenegger, J. Bartram, S. Ronchi, A. Hierlemann, M. Schröter, D. Roqueiro, "Predicting in vitro single-neuron firing rates upon pharmacological perturbation using graph neural networks", Frontiers in Neuroinformatics 2022, 16, Article 1032538 (DOI: 10.3389/fninf.2022.1032538). external page Online
J. Lee, T. Gänswein, H. Ulusan, V. Emmenegger, A. Saguner, F. Duru, A. Hierlemann, "Repeated and on-demand intracellular recordings of cardiomyocytes derived from human-induced pluripotent stem cells", ACS Sensors 2022, 7 (10), p. 3181–3191 (DOI: 10.1021/acssensors.2c01678). external page Online
X. Xue, A. P. Buccino, S. Saseendran Kumar, A. Hierlemann, and J. Bartram, "Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking", Journal of Neural Engineering 2022, 19 (4), Article 046044 (DOI: 10.1088/1741-2552/ac8765). external page Online
R. Castellanos-Rueda, R. Di Roberto, F. Bieberich, F. Schlatter, D. Palianina, O. Nguyen, E. Kapetanovic, H. Läubli, A. Hierlemann, N. Khanna, S. Reddy, "SpeedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing", Nature Communications 2022, 13, Article 6555 (DOI: 10.1038/s41467-022-34141-8). external page Online
M. Schröter, C. Wang, M. Terrigno, P. Hornauer, Z. Huang, R. Jagasia, A. Hierlemann, "Functional imaging of brain organoids using high-density microelectrode arrays", MRS Bulletin 2022, 47, p. 530–544 (DOI: 10.1557/s43577-022-00282-w). external page Online
S. Kumar, T. Gänswein, A. Buccino, X. Xue, J. Bartram, V. Emmenegger, A. Hierlemann, "Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study", Frontiers in Neuroinformatics 2022, 16, Article 957255 (DOI: 10.3389/fninf.2022.957255). external page Online
N. Rousset, C. Lohasz, J. A. Boos, P. M. Misun, F. Cardes, and A. Hierlemann, "Circuit-based design of microfluidic drop networks", Micromachines 2022, 13 (7), p. 1124 (DOI: 10.3390/mi13071124). Online
T. Sharf, T. van der Molen, S. Glasauer, E. Guzman, A. Buccino, G. Luna, Z. Cheng, M. Audouard, K. Ranasinghe, K. Kudo, S. Nagarajan, K. Tovar, L. Petzold, A. Hierlemann, P. Hansma, Paul, K. Kosik, "Functional neuronal circuitry and oscillatory dynamics in human brain organoids", Nature Communications 2022, Vol. 13, No. 1, p. 4403, (DOI: 10.1038/s41467-022-32115-4). external page Online
R. Bounik, F. Cardes, H. Ulusan, M. Modena, A. Hierlemann, "Impedance imaging of cells and tissues: design and applications", BME Frontiers 2022, Article 9857485 (DOI: 10.34133/2022/9857485). external page Online
B. Yesildag, J. Mir-Coll, A. Neelakandhan, C. B. Gibson, N. R. Perdue, C. Rufer, M. Karsai, A. Biernath, F. Forschler, P. Wu Jin, P. M. Misun, A. Hierlemann, F. F. Kreiner, J. D. Wesley, M. G. von Herrath, "Liraglutide protects β-cells in novel human islet spheroid models of type 1 diabetes", Clinical Immunology 2022, Volume 244, Article 109118 (DOI: 10.1016/j.clim.2022.109118). external page Online
P. S. Ravaynia, S. Biendl, F. Grassi, J. Keiser, A. Hierlemann, M. M. Modena, "Real-time and automated monitoring of antischistosomal drug activity profiles for screening of compound libraries", iScience 2022, 25 (4), 104087 (DOI: 10.1016/j.isci.2022.104087). external page Online
A. Buccino, X. Yuan, V. Emmenegger, X. Xue, T. Gänswein, A. Hierlemann, "An automated method for precise axon reconstruction from recordings of high-density micro-electrode arrays", Journal of Neural Engineering 2022, 19 (2), Article 026026 (DOI: /10.1088/1741-2552/ac59a2). external page Online
V. Sessi, B. Ibarlucea, F. Seichepine, S. Klinghammer, I. Ibrahim, A. Heinzig, N. Szabo, T. Mikolajick, A. Hierlemann, U. Frey, W. Weber, L. Baraban, G. Cuniberti, "Multisite dopamine sensing with femtomolar resolution using a CMOS-enabled aptasensor chip", Frontiers in Neuroscience 2022, Vol. 16, Article 875656 (DOI: 10.3389/fnins.2022.875656). external page Online
N. Rousset, R. Sandoval, M. Modena, A. Hierlemann, P. Misun, "Modeling and measuring glucose diffusion and consumption by colorectal cancer spheroids in hanging drops using integrated biosensors", Microsystems & Nanoengineering 2022, Vol. 8, Article 14 (DOI: 10.1038/s41378-021-00348-w). external page Online
2021
C. Lohasz, J. Loretan, D. Sterker, E. Görlach, K. Renggli, P. Argast, O. Frey, M. Wiesmann, M. Wartmann, M. Rausch, A. Hierlemann, "A microphysiological cell-culturing system for pharmacokinetic drug exposure and high-resolution imaging of arrays of 3D microtissues", Frontiers in Pharmacology 2021,12:785851 (DOI: 10.3389/fphar.2021.785851). external page Online
J. Boos, P. Misun, G. Brunoldi, L. Furer, L. Aengenheister, M. Modena, N. Rousset, T. Buerki-Thurnherr, Andreas Hierlemann, "Microfluidic co-culture platform to recapitulate the maternal–placental–embryonic axis", Advanced Biology 2021, Article 2100609 (DOI: 10.1002/adbi.202100609). external page Online
O. T. P. Nguyen, P. M. Misun, C. Lohasz, J. Lee, W. Wang, T. Schroeder, A. Hierlemann, "An immunocompetent microphysiological system to simultaneously investigate effects of anti-tumor natural killer cells on tumor and cardiac microtissues", Frontiers in Immunology 2021, Article 781337 (DOI: 10.3389/fimmu.2021.781337). external page Online
F. Gökçe, P. S. Ravaynia, M. M. Modena, A. Hierlemann, "What is the future of electrical impedance spectroscopy in flow cytometry?", Biomicrofluidics 2021, 15, 061302 (DOI: 10.1063/5.0073457). external page Online
X. Yuan, A. Hierlemann, U. Frey, "Extracellular recording of entire neural networks using a dual-mode microelectrode array with 19,584 electrodes and high SNR", IEEE Journal of Solid-State Circuits 2021, Vol. 56(8), pp. 2466-2475 (DOI: 10.1109/JSSC.2021.3066043). external page Online
S. Ronchi, A. Buccino, G. Prack, S. Kumar, M. Schröter, M. Fiscella, A. Hierlemann, "Electrophysiological phenotype characterization of human iPSC‐derived neuronal cell lines by means of high‐density microelectrode arrays", Advanced Biology 2021, Article 2000223 (DOI: 10.1002/adbi.202000223). external page Online
F. Cardes, N. Baladari, J. Lee, A. Hierlemann, "A Low-power opamp-less second-order delta-sigma modulator for bioelectrical signals in 0.18 µm CMOS", Sensors 2021, 21, 6456 (DOI: 10.3390/s21196456). external page Online
I. El-Battrawy, H. Lan, L. Cyganek, L. Maywald, R. Zhong, F. Zhang, Q. Xu, J. Lee, E. Duperrex, A. Hierlemann, A. Saguner, F. Duru, B. Kovacs, M. Huang, Z. Liao, S. Albers, J. Müller, H. Dinkel, L. Rose, A. Hohn, Z. Yang, L. Qiao, Y. Li, S. Lang, M. Kleinsorge, A. Mügge, A. Aweimer, X. Fan, S. Diecke, I. Akin, G. Li, X. Zhou, "Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene-edited human-induced pluripotent stem cell-derived cardiomyocytes and preclinical drug screening", Clinical and Translational Medicine 2021, 11: e646 (DOI: 10.1002/ctm2.646). external page Online
P. Jin, N. Rousset, A. Hierlemann, P. Misun, "A microfluidic hanging-drop-based islet perifusion system for studying glucose-stimulated insulin secretion from multiple individual pancreatic islets", Frontiers in Bioengineering and Biotechnology 2021, Vol. 9, pp. 352 (DOI: 10.3389/fbioe.2021.674431). external page Online
Z. Zhu, Y. Wang, R. Peng, P. Chen, Y. Geng, B. He, S. Ouyang, K.Zheng, Y. Fan, D. Pan, N. Jin, F. Rudolf, A. Hierlemann, "A microfluidic single-cell array for in situ laminar-flow-based comparative culturing of budding yeast cells", Talanta 2021, Volume 231, 122401 (DOI: 10.1016/j.talanta.2021.122401). external page Online
2020
X. Yuan, M. Schröter, M. Engelene J. Obien, M. Fiscella, W. Gong, T. Kikuchi, A. Odawara, S. Noji, I. Suzuki, J. Takahashi, A. Hierlemann, U. Frey, "Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level", Nature Communications 2020, 11, 4854 (DOI: 10.1038/s41467-020-18620-4). external page Online
C. Lohasz, F. Bonanini, L. Hoelting, K. Renggli, O. Frey, A. Hierlemann, "Predicting metabolism‐related drug–drug interactions using a microphysiological multitissue system", Advanced Biosystems 2020, Article 2000079 (DOI: 10.1002/adbi.202000079). external page Online
P. S. Ravaynia, F. C. Lombardo, S. Biendl, M. A. Dupuch, J. Keiser, A. Hierlemann, M. M. Modena, "Parallelized impedance‐based platform for continuous dose‐response characterization of antischistosomal drugs", Advanced Biosystems 2020, Article 1900304 (DOI: 10.1002/adbi.201900304). external page Online
F. Lombardo, P. Ravaynia, M. Modena, A. Hierlemann, and J. Keiser, "Evaluation of human liver microtissues for drug screening on schistosoma mansoni schistosomula", ACS Infectious Diseases 2020, in press (DOI: 10.1021/acsinfecdis.0c00614). external page Online
C. Cowan, M. Renner, M. De Gennaro, B. Gross-Scherf, D. Goldblum, Y. Hou, M. Munz, T. Rodrigues, J. Krol, T. Szikra, R. Cuttat, A. Waldt, P. Papasaikas, R. Diggelmann, C. P. Patino-Alvarez, P. Galliker, S. E. Spirig, D. Pavlinic, N. Gerber-Hollbach, S. Schuierer, A. Srdanovic, M. Balogh, R. Panero, A. Kusnyerik, A. Szabo, M. Stadler, S. Orgül, S. Picelli, P. Hasler, A. Hierlemann, H. Scholl, G. Roma, F. Nigsch, B. Roska, "Cell types of the human retina and its organoids at single-cell resolution", Cell 2020, Vol. 182(6), pp. 1623-1640.e34 (DOI: 10.1016/j.cell.2020.08.013). external page Online
L. Dong, P. S. Ravaynia, Q. A. Huang, A. Hierlemann, M. M. Modena, "Parallelized wireless sensing system for continuous monitoring of microtissue spheroids", ACS Sensors 2020, 5 (7), 2036–2043 (DOI: 10.1021/acssensors.0c00481). external page Online
I. Mannaerts, N. Eysackers, E. A. van Os, S. Verhulst, T. Roosens, A. Smout, A. Hierlemann, O. Frey, S. Batista Leite, L. A. van Grunsven, "The fibrotic response of primary liver spheroids recapitulates in vivo hepatic stellate cell activation", Biomaterials 2020, Vol. 261, Article 120335 (DOI: 10.1016/j.biomaterials.2020.120335). external page Online
L. L. Sohn, P. Schwille, A. Hierlemann, S. Tay, J. Samitier, J. Fu, P. Loskill, "How can microfluidic and microfabrication approaches make experiments more physiologically relevant?", Cell Systems 2020, September Voices (DOI: 10.1016/j.cels.2020.07.003). external page Online
M. Kollo, R. Racz, M.-E. Hanna, A. Obaid, M.R. Angle, W. Wray, Y. Kong, J. Müller, A. Hierlemann, N. A. Melosh, A.T. Schaefer, "CHIME: CMOS-hosted in vivo microelectrodes for massively scalable neuronal recordings", Front. Neurosci. 2020, 14:834 (DOI: 10.3389/fnins.2020.00834). external page Online
R. Nudischer, K. Renggli, A. Hierlemann, A. B. Roth, C. Bertinetti-Lapatki, "Characterization of a long-term mouse primary liver 3D tissue model recapitulating innate-immune responses and drug-induced liver toxicity", PLoS ONE 2020, 15(7):e0235745 (DOI: 10.1371/journal.pone.0235745). external page Online
A. Obaid, M. E. Hanna, Y.-W. Wu, M. Kollo, R. Racz, M. R. Angle, J. Müller, N. Brackbill, W. Wray, F. Franke, E. J. Chichilnisky, A. Hierlemann, J. B. Ding, A. T. Schaefer, N. A. Melosh, "Massively parallel microwire arrays integrated with CMOS chips for neural recording", Science Advances 2020, 6 (12), Article eaay2789 (DOI: 10.1126/sciadv.aay2789). external page Online
P. Misun, B. Yesildag, F. Forschler, A. Neelakandhan, N. Rousset, A. Biernath, A. Hierlemann, O. Frey, "In-vitro platform for studying human insulin release dynamics of single pancreatic islet microtissues at high resolution", Advanced Biosystems 2020, Article 1900291 (DOI: 10.1002/adbi.201900291). external page Online
R. Nudischer, K. Renggli, C. Bertinetti-Lapatki, J.-C. Hoflack, N. Flint, S. Sewing, L. Pedersen, S. Schadt, L. G Higgins, A. Vardy, B. Lenz, L. Gand, F. Boess, B. M. Elcombe, A. Hierlemann, A. B Roth, "Combining in vivo and organotypic in vitro approaches to assess the human relevance of Basimglurant (RG7090), a potential CAR activator", Toxicological Sciences 2020, Article kfaa076, (DOI: 10.1093/toxsci/kfaa076). Online
B. Gaub, K. Kasuba, E. Mace, T. Strittmatter, P. Laskowski, S. Geissler, A.Hierlemann, M. Fussenegger, B. Roska, D. Müller, "Neurons differentiate magnitude and location of mechanical stimuli", Proceedings of the National Academy of Sciences 2020, 117 (2), pp. 848-856 (DOI: 10.1073/pnas.1909933117). external page Online
2019
J. Boos, P. Misun, A. Michlmayr, A. Hierlemann, O. Frey, "Microfluidic multitissue platform for advanced embryotoxicity testing in vitro", Advanced Science 2019, Article 1900294 (DOI: 10.1002/advs.201900294). external page Online
V. Viswam, M. Engelene Obien, F. Franke, U. Frey, A. Hierlemann, "Optimal electrode size for multi-scale extracellular-potential recording from neuronal assemblies", Frontiers in Neuroscience 2019, 13, Article 385 (DOI: 10.3389/fnins.2019.00385). external page Online
V. Emmenegger, M. Engelene Obien, F. Franke, A. Hierlemann, "Technologies to study action potential propagation with a focus on HD-MEAs", Frontiers in Cellular Neuroscience 2019, 13, Article 159 (DOI: 10.3389/fncel.2019.00159). external page Online
A. Dudina, U. Frey, A. Hierlemann, "Carbon-nanotube-based monolithic CMOS platform for electrochemical detection of the neurotransmitter glutamate", Sensors 2019, 19 (14), 3080 (DOI: 10.3390/s19143080). external page Online
T. Bullmann, M. Radivojevic, S. Huber, K. Deligkaris, A. Hierlemann, U. Frey, "Large-scale mapping of axonal arbors using high-density microelectrode arrays", Frontiers in Cellular Neuroscience 2019, 13, Article 404 (DOI: 10.3389/fncel.2019.00404) external page Online.
T. Russell, J. Zhang, M. Okoniewski, F. Franke, S. Bichet, A. Hierlemann, "Medullary respiratory circuit is reorganized by a seasonally-induced program in preparation for hibernation", Frontiers in Neuroscience 2019, 13, Article 376 (DOI: 10.3389/fnins.2019.00376). external page Online
K. Renggli, N. Rousset, C. Lohasz, O.T.P. Nguyen, A. Hierlemann, "Integrated microphysiological systems: Transferable organ models and recirculating flow", Advanced Biosystems 2019, Article 1900018 (DOI: 10.1002/adbi.201900018). external page Online
C. Lohasz, O. Frey, F. Bonanini, K. Renggli, A. Hierlemann, "Tubing-free microfluidic microtissue culture system featuring gradual, in vivo-like substance exposure profiles", Frontiers in Bioengineering and Biotechnology 2019, 7, Article 72 (DOI: 10.3389/fbioe.2019.00072). Online
S. Ronchi, M. Fiscella, C. Marchetti, V. Viswam, J. Müller, U. Frey, A. Hierlemann, "Single-cell electrical stimulation using CMOS-based high-density microelectrode arrays", Frontiers in Neuroscience 2019, 13, Article 208 (DOI: 10.3389/fnins.2019.00208). external page Online
T. Mita, D. Bakkum, U. Frey, A. Hierlemann, R. Kanzaki, H. Takahashi, "Classification of inhibitory and excitatory neurons of dissociated cultures based on action-potential waveforms on high-density CMOS microelectrode arrays", IEEJ Transactions on Electronics, Information and Systems 2019, 139 (5), pp. 615-624 (DOI: 10.1541/ieejeiss.139.615). external page Online
M. Engelene Obien, A. Hierlemann, U. Frey, "Accurate signal-source localization in brain slices by means of high-density microelectrode arrays", Scientific Reports 2019, Vol. 9, Article 788 (DOI: 10.1038/s41598-018-36895-y). external page Online
A. Dudina, F. Seichepine, Y. Chen, A. Stettler, A. Hierlemann, U. Frey, "Monolithic CMOS sensor platform featuring an array of 9’216 carbon-nanotube-sensor elements and low-noise, wide-bandwidth and wide-dynamic-range readout circuitry", Sensors & Actuators B (Chemical) 2019, Vol. 279, pp. 255-266 (DOI: 10.1016/j.snb.2018.10.004). external page Online
A. Shadmani, V. Viswam, Y. Chen, R. Bounik, J. Dragas, M. Radivojevic, S. Geissler, S. Sitnikov, J. Müller, A. Hierlemann, "Stimulation and artifact-suppression techniques for in-vitro high-density microelectrode array systems", IEEE Transactions on Biomedical Engineering, 2019, 66 (9), pp. 2481-2490 (DOI: 10.1109/TBME.2018.2890530). external page Online
D. Bakkum, M. Engelene J. Obien, M. Radivojevic, D. Jäckel, U. Frey, H. Takahashi, A. Hierlemann, "The axon initial segment is the dominant contributor to the neuron's extracellular electrical potential landscape", Advanced Biosystems 2019, 3, 1800308 (DOI: 10.1002/adbi.201800308). external page Online
2018
K. Chawla, M. Modena, P. Ravaynia, F. Lombardo, M. Leonhardt, G. Panic, S. Bürgel, J. Keiser, and A. Hierlemann, "Impedance-based microfluidic assay for automated antischistosomal drug screening", ACS Sensors 2018, 3 (12), pp. 2613–2620 (DOI: 10.1021/acssensors.8b01027). external page Online
V. Viswam, R. Bounik, A. Shadmani, J. Dragas, C. Urwyler, J. Boos, M. Obien, J. Müller, Y. Chen, A. Hierlemann, "Impedance spectroscopy and electrophysiological imaging of cells with a high-density CMOS microelectrode array system", IEEE Trans. Biomed. Circuits Syst. 2018, 12 (6), pp. 1356-1368 (DOI: 10.1109/TBCAS.2018.2881044). external page Online
M. Lewandowska, E. Bogatikov, A. Hierlemann, A. Rostedt Punga, "Long-term high-density extracellular recordings enable studies of muscle cell physiology", Frontiers in Physiology 2018, Vol. 9, article 1424 (DOI: 10.3389/fphys.2018.01424). external page Online
C. Lohasz, N. Rousset, K. Renggli, A. Hierlemann, O. Frey, "Scalable microfluidic platform for flexible configuration of and experiments with microtissue multiorgan models", SLAS Technology 2018, in press, pp. 1-17 (DOI: 10.1177/2472630318802582). external page Online
R. Diggelmann, M. Fiscella, A. Hierlemann, F. Franke, "Automatic Spike Sorting Algorithm for High-Density Microelectrode Arrays", Journal of Neurophysiology 2018, 120 (6), pp. 3155–3171 (DOI: 10.1152/jn.00803.2017). external page Online
A. Drinnenberg, F. Franke, R. K. Morikawa, J. Jüttner, D. Hillier, P. Hantz, A. Hierlemann, R. A. da Silveira, B. Roska, "How diverse retinal functions arise from feedback at the first visual synapse", Neuron 2018, Vol. 99 (1), pp. 117-134.e11 (DOI: 10.1016/j.neuron.2018.06.001). external page Online / external page Preview
B. van Lier, A. Hierlemann, F. Knoflach, "Parvalbumin expression and gamma oscillation occurrence increase over time in a neurodevelopmental model of NMDA receptor dysfunction", PeerJ 2018-09-19 (DOI: 10.7717/peerj.5543). external page Online
K. Chawla, S Bürgel, G. Schmidt, H-M. Kaltenbach, F. Rudolf, O. Frey, Andreas Hierlemann, "Integrating impedance-based growth-rate monitoring into a microfluidic cell culture platform for live-cell microscopy", Microsystems & Nanoengineering 2018, 4:8 (DOI 10.1038/s41378-018-0006-5). external page Online
E. Aeby, P. Misun, A. Hierlemann, O. Frey, "Microfluidic hydrogel hanging-drop network for long-term culturing of 3D microtissues and simultaneous high-resolution imaging", Advanced Biosystems 2018, 2, 1800054 (DOI: 10.1002/adbi.201800054). external page Online
Yonghong Tao, Andreas Hierlemann, "A 15-channel 30-V neural stimulator for spinal cord repair", IEEE Transactions on Very Large Scale Integration (VLSI) Systems 2018, Vol. 26 (10), pp. 2185-2189 (DOI: 10.1109/TVLSI.2018.2832051). external page Online
M. Modena, K. Chawla, P. Misun, A. Hierlemann, "Smart cell-culture systems: Integration of sensors and actuators into microphysiological systems", ACS Chem. Biol. 2018, 13 (7), pp 1767–1784 (DOI: 10.1021/acschembio.7b01029). external page Online
2017
M. Radivojevic, F. Franke, M. Altermatt, J. Müller, A. Hierlemann, D. Bakkum, "Tracking individual action potentials throughout mammalian axonal arbors", eLife 2017, 6:e30198 (DOI: 10.7554/eLife.30198). external page Online
J. Dragas, V. Viswam, A. Shadmani, Y. Chen, R. Bounik, A. Stettler, M. Radivojevic, S. Geissler, M. Engelene J. Obien, J. Müller, A. Hierlemann, "In-vitro multi-functional microelectrode array featuring 59760 electrodes, 2048 electrophysiology channels, stimulation, impedance measurement and neurotransmitter detection channels", IEEE Journal of Solid-State Circuits, 2017, Volume 52 (6), pp. 1576-1590 (DOI:10.1109/JSSC.2017.2686580). external page Online
D. Hillier, M. Fiscella, A. Drinnenberg, S. Trenholm, S.B. Rompani, Z. Raics, G. Katona, J. Juettner, A. Hierlemann, B. Rozsa, B. Roska, "Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex", Nature Neuroscience 2017, Vol. 20, pp. 960–968 (DOI:10.1038/nn.4566). external page Online
D. Jäckel, D. J. Bakkum, T. L. Russell, J. Müller, M. Radivojevic, U. Frey, F. Franke & A. Hierlemann, "Combination of high-density microelectrode array and patch clamp recordings to enable studies of multisynaptic integration", Scientific Reports 2017, Vol. 7, Art. No. 978 (DOI:10.1038/s41598-017-00981-4). external page Online
F. Seichepine, J. Rothe, A. Dudina, A. Hierlemann, and U. Frey, "Dielectrophoresis-assisted integration of 1024 carbon nanotube sensors into a CMOS microsystem", Advanced Materials, 2017, Vol. 29, No. 17, p. 1606852 (DOI: 10.1002/adma.201606852). external page Online
J. Rothe, O. Frey, R. Madangopal, J. Rickus, Andreas Hierlemann, "Robust functionalization of large microelectrode arrays by using pulsed potentiostatic deposition", Sensors 2017, 17(1), 22 (DOI:10.3390/s17010022). external page Online
Y. Yada, T. Mita, A. Sanada, R. Yano, R. Kanzaki, D. Bakkum, A. Hierlemann, H. Takahashi, "Development of neural population activity towards self-organized criticality", Neuroscience 2017, 343, pp. 555-565 (DOI: 10.1016/j.neuroscience.2016.11.031). external page Online
2016
W. Gong, J. Senčar, D.J. Bakkum, D. Jäckel, M. Engelene J. Obien, M. Radivojevic, and A. Hierlemann, "Multiple single-unit long-term tracking on organotypic hippocampal slices using high-density microelectrode arrays", Front. Neurosci. 2016, 10:537 (DOI: 10.3389/fnins.2016.00537). external page Online
S. Bürgel, L. Diener, O. Frey, J.Y. Kim, A. Hierlemann, "Automated, multiplexed electrical impedance spectroscopy platform for continuous monitoring of microtissue spheroids", Analytical Chemistry 2016, 88 (22), pp. 10876–10883 (DOI: 10.1021/acs.analchem.6b01410). external page Online
M. Radivojevic, D. Jäckel, M. Altermatt, J. Müller, V. Viswam, A. Hierlemann, D. Bakkum, "Electrical identification and selective microstimulation of neuronal compartments based on features of extracellular action potentials", Scientific Reports 2016, 6, 31332 (DOI:10.1038/srep31332). external page Online
K. Deligkaris, T. Bullmann, and U. Frey, “Extracellularly recorded somatic and neuritic signal shapes and classification algorithms for high-density microelectrode array electrophysiology”, Front. Neurosci., 10:421, 2016, (DOI: 10.3389/fnins.2016.00421). external page Online
P. Misun, J. Rothe, Y. Schmid, A. Hierlemann, O. Frey, "Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks", Microsystems & Nanoengineering, 2016, 2, article 16022 (DOI: 10.1038/micronano.2016.22). external page Online
Y. Schmid, S. Bürgel, P. Misun, A. Hierlemann, O. Frey, "Electrical impedance spectroscopy for microtissue spheroid analysis in hanging-drop networks", ACS Sensors 2016, 1 (8), pp 1028–1035 (DOI: 10.1021/acssensors.6b00272). external page Online
N. Haandbaek, S. C. Bürgel, F. Rudolf, F. Heer, and A. Hierlemann, "Characterization of single yeast cell phenotypes using microfluidic impedance cytometry and optical imaging", ACS Sensors 2016, 1 (8), pp 1020–1027 (DOI: 10.1021/acssensors.6b00286). external page Online
M. K. Lewandowska, M. Radivojević, D. Jäckel, J. Müller, and A. Hierlemann, "Cortical axons, isolated in channels, display activity-dependent signal modulation as a result of targeted stimulation", Front. Neurosci. 2016, 10:83 (DOI: 10.3389/fnins.2016.00083). external page Online
K. Yonehara, M. Fiscella, A. Drinnenberg, F. Esposti, S. Trenholm, J. Krol, F. Franke, B. Gross-Scherf, A. Kusnyerik, J. Müller, A. Szabo, J. Jüttner, F. Cordoba, A. P. Reddy, J. Németh, Z. Nagy, F. Munier, A. Hierlemann, B. Roska, "Congenital nystagmus gene FRMD7 is necessary for establishing a neuronal circuit asymmetry for direction selectivity", Neuron, 2016, 89(1), pp. 177-193 (DOI: 10.1016/j.neuron.2015.11.032). external page Online / external page Video abstract
Received external page Swiss OphthAward 2016 of the external page Swiss Society of Ophthalmology in Category Best Experimental Work.
F. Franke, M. Fiscella, M. Sevelev, B. Roska, A. Hierlemann, R. Azeredo da Silveira, "Structures of neural correlation and how they favor coding", Neuron, 2016, 89(2), pp. 409-422 (DOI: 10.1016/j.neuron.2015.12.037). external page Online
A. Birchler, M. Berger, V. Jaeggin, T. Lopes, M. Etzrodt, P. Misun, M. Pena-Francesch, T. Schroeder, A. Hierlemann, O. Frey, "Seamless combination of FACS and hanging-drop networks for individual handling and culturing of stem cells and microtissue spheroids", Analytical Chemistry, 2016, 88 (2), pp. 1222–1229 (DOI: 10.1021/acs.analchem.5b03513). external page Online
R. F. Steinhoff, D. J. Karst, F. Steinebach, M. R. Kopp, G. W. Schmidt, A. Stettler, J. Krismer, M. Soos, M. Pabst, A. Hierlemann, M. Morbidelli, R. Zenobi, "Microarray-based MALDI-TOF mass spectrometry enables monitoring of monoclonal antibody production in batch and perfusion cell cultures", Methods, 2016, 104, pp. 33-40 (DOI: 10.1016/j.ymeth.2015.12.011). external page Online
2015
B. Sorce, C. Escobedo, Y. Toyoda, M. Stewart, C. Cattin, R. Newton, I. Banerjee, A. Stettler, B. Roska, S. Eaton, A. Hyman, A. Hierlemann, D. J. Müller, "Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement", Nature Communications, 2015, 6:8872 (DOI: 10.1038/ncomms9872). external page Online
Z. Zhu, O. Frey, N. Haandbaek, F. Franke, F. Rudolf, A. Hierlemann, "Time-lapse electrical impedance spectroscopy for monitoring the cell cycle of single immobilized S. pombe cells", Scientific Reports, 2015, 5, 17180 (DOI: 10.1038/srep17180). external page Online
I. L. Jones, T. L. Russell, K. Farrow, M. Fiscella, F. Franke, J. Müller, D. Jäckel and A. Hierlemann, "A method for electrophysiological characterization of hamster retinal ganglion cells using a high-density CMOS microelectrode array", Front. Neurosci., 2015, 9:360 (DOI: 10.3389/fnins.2015.00360). external page Online
S. Rismani Yazdi, A. Shadmani, S. Bürgel, P. Misun, A. Hierlemann, O. Frey, "Adding the 'heart' to hanging drop networks for microphysiological multi-tissue experiments", Lab Chip, 2015, 15, pp. 4138- 4147 (DOI: 10.1039/C5LC01000D). external page Online
P. Livi, M. Kwiat, A. Shadmani, J. Rothe, G. Navarra, A. Pevzner, A. Stettler, Y. Chen, F. Patolsky, and A. Hierlemann, "Monolithic integration of a silicon nanowire FET array on a CMOS chip for bio-chemical sensor applications", Anal. Chem., 2015, 87 (19), pp 9982–9990 (DOI: 10.1021/acs.analchem.5b02604). external page Online
K. Liu, Z. Zhu, X. Wang, D. Gonçalves, B. Zhang, A. Hierlemann, P. Hunziker "Microfluidics-based single-step preparation of injection-ready polymeric nanosystems for medical imaging and drug delivery", Nanoscale, 2015, 7, 16983-16993 (DOI: 10.1039/C5NR03543K). external page Online
M. Fiscella, F. Franke, K. Farrow, J. Müller, B. Roska, R. Azeredo da Silveira, A. Hierlemann, "Visual coding with a population of direction-selective neurons", Journal of Neurophysiology, 2015 (DOI: 10.1152/jn.00919.2014). external page Online
J. Krol, I. Krol, C. P. Patino Alvarez, M. Fiscella, A. Hierlemann, B. Roska, W. Filipowicz, "A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture", Nature Communications, 2015, 6:7305 (DOI:10.1038/ncomms8305). external page Online
C. R. Escobedo, S. C. Bürgel, S. Kemmerling, N. Sauter, T. Braun, A. Hierlemann, "On-chip lysis of mammalian cells through a handheld corona device", Lab Chip, 2015, 15, pp. 2990-2997 (DOI: 10.1039/C5LC00552C). external page Online
J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, A. Hierlemann, "High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels", Lab Chip, 2015, 15, pp. 2767-2780 (DOI: 10.1039/C5LC00133A). external page Online
O. Frey, F. Rudolf, G. W. Schmidt, A. Hierlemann, "Versatile, simple-to-use microfluidic cell-culturing chip for long-term, high-resolution, time-lapse imaging", Anal. Chem., 2015, 87 (8), pp. 4144–4151 (DOI: 10.1021/ac504611t). external page Online
Y. Tao, A. Hierlemann, Y. Lian, "A frequency-domain analysis of latch comparator offset due to load capacitor mismatch", IEEE Transactions on Circuits and Systems II, 2015, 62 (6), pp. 527-532 (DOI: 10.1109/TCSII.2015.2406832). external page Online
J. Dragas, D. Jaeckel, A. Hierlemann, F. Franke, "Complexity Optimisation and High-Throughput Low-Latency Hardware Implementation of a Multi-Electrode Spike-Sorting Algorithm", IEEE Trans. On Neural Systems and Rehabilitation Engineering, 2015, 23(2), pp. 149-158 (DOI: 10.1109/TNSRE.2014.2370510). external page Online
M. K. Lewandowska, D. J. Bakkum, S. B. Rompani, A. Hierlemann, "Recording Large Extracellular Spikes in Microchannels along Many Axonal Sites from Individual Neurons", PLoS ONE, 2015, 10(3): e0118514 (DOI: 10.1371/journal.pone.0118514). external page Online
F. Franke, R. Q. Quiroga, A. Hierlemann, K. Obermayer "Bayes Optimal Template Matching for Spike Sorting - Combining Fisher Discriminant Analysis with Optimal Filtering", Journal of Computational Neuroscience, 2015, 38 (3), pp. 439-459 (DOI: 10.1007/s10827-015-0547-7). external page Online
J-Y. Kim, D. Fluri, R. Marchan, K. Boonen, S. Mohanty, P. Singh, S. Hammad, B. Landuyt, J. G Hengstler, J. M. Kelm, A. Hierlemann, O. Frey, "3D Spherical Microtissues and Microfluidic Technology for Multi-tissue Experiments and Analysis", Journal of Biotechnology, 2015, 205, pp. 24–35 (DOI: 10.1016/j.jbiotec.2015.01.003). external page Online
S. C Bürgel, C. Escobedo, N. Haandbæk, A. Hierlemann, "On-chip Electroporation and Impedance Spectroscopy of Single Cells", Sensors and Actuators B: Chemical, 2015, 210, pp. 82-90 (DOI: 10.1016/j.snb.2014.12.016). external page Online
S. Okawa, T. Mita, D. Bakkum, U. Frey, A. Hierlemann, R. Kanzaki, H. Takahashi, "Chronic Co‐Variation of Neural Network Configuration and Activity in Mature Dissociated Cultures", Electronics and Communications in Japan 98 (5), pp. 34-42 (DOI: 10.1002/ecj.11736). external page Online
J. Kim, D.A. Fluri, J.M. Kelm, A. Hierlemann, O. Frey, "96-Well Format-Based Microfluidic Platform for Parallel Interconnection of Multiple Multicellular Spheroids", Journal of Laboratory Automation, 2015, 20(3), pp. 274–282 (DOI: 10.1177/2211068214564056). external page Online
2014
O. Frey, P. Misun, D. Fluri, J. Hengstler, A. Hierlemann, "Reconfigurable Microfluidic Hanging-drop Network for Multi-tissue interaction and Analysis", Nature Communications, 2014, 5:4250 (DOI: 10.1038/ncomms5250). external page Online
Received Highly Commended Award in the 2014 external page 3Rs Prize competition of the British external page NC3Rs.
M. Ballini, J. Mueller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. Jones, D. Jäckel, M. Radivojevic, M. Lewandowska, W. Gong, M. Fiscella, D. Bakkum, F. Heer, and A. Hierlemann, "A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro", IEEE Journal of Solid-State Circuits, 2014, 49, pp. 2705–2719 (DOI: 10.1109/JSSC.2014.2359219). external page Online
M.J. Obien, K. Deligkaris, T. Bullmann, D.J. Bakkum, U. Frey, "Revealing Neuronal Function through Microelectrode Array Recordings", Frontiers in Neuroscience 8:423, 2014 (DOI: 10.3389/fnins.2014.00423). external page Online
P. Livi, A. Shadmani, M. Wipf, R. Stoop, J. Rothe, Y. Chen, M. Calame, C. Schönenberger, A. Hierlemann, "Sensor System including Silicon Nanowire Ion Sensitive FET Arrays and CMOS readout", Sensors and Actuators B: Chemical, 2014, 204 (1), pp 568–577 (DOI: 10.1016/j.snb.2014.08.002). external page Online
D. Ausländer, S. Ausländer, G. Charpin-El Hamri, F. Sedlmayer, M. Müller, O. Frey, A. Hierlemann, J. Stelling, M. Fussenegger, "A Synthetic Multifunctional Mammalian pH Sensor and CO2 Transgene-Control Device", Molecular Cell, 2014, 55, 1-12 (DOI: 10.1016/j.molcel.2014.06.007). external page Online
Z. Zhu, O. Frey, F. Franke, N. Haandbæk, A. Hierlemann, "Real-time Monitoring of Immobilized Single Yeast Cells through Multifrequency Electrical Impedance Spectroscopy", Analytical and Bioanalytical Chemistry, 2014, 406 (27): 7015-7025 (DOI: 10.1007/s00216-014-7955-9). external page Online
N. Haandbaek, S. C. Bürgel, F. Heer and A. Hierlemann, "Resonance-enhanced Microfluidic Impedance Cytometer for Detection of Single Bacteria", Lab on a Chip, 2014, 14, 3313-3324 (DOI: 10.1039/C4LC00576G). external page Online
J. Rothe, O. Frey, A. Stettler, Y. Chen, A. Hierlemann, "Fully Integrated CMOS Microsystem for Electrochemical Measurements on 32× 32 Working Electrodes at 90 Frames Per Second", Anal. Chem., 2014, 86 (13), pp. 6425–6432 (DOI: 10.1021/ac500862v). external page Online
N. Haandbaek, S. C. Bürgel, F. Heer and A. Hierlemann, "Characterization of Subcellular Morphology of Single Yeast Cells Using High Frequency Microfluidic Impedance Cytometer", Lab on a Chip, 2014, 14(2), pp. 369-377, (DOI: 10.1039/C3LC50866H). external page Online
2013
D.J Bakkum, M. Radivojevic, U. Frey, F. Franke, A. Hierlemann and H. Takahashi "Parameters for Burst Detection", Front. Comput. Neurosci. 2013, 7:193 (DOI:10.3389/fncom.2013.00193). external page Online
O. Frey, J. Rothe, F. Heer, P. D. van der Wal, N. F. de Rooij and A. Hierlemann, "Multi-site Monitoring of Choline Using Biosensor Microprobe Arrays in Combination with CMOS Circuitry", Biomedical Engineering/Biomedizinische Technik, 2013 (DOI: 10.1515/bmt-2012-0098). external page Online
N. Haandbaek, S. C. Bürgel, F. Heer and A. Hierlemann,"Development of a Microfluidic GHz Impedance Cytometer", tm – Technisches Messen, 2013, 80(12), pp. 411–420 (DOI: 10.1524/teme.2013.0053). external page Online
Douglas J. Bakkum, Urs Frey, Milos Radivojevic, Thomas L. Russell, Jan Müller, Michele Fiscella, Hirokazu Takahashi, Andreas Hierlemann, "Tracking Axonal Action Potential Propagation on a High-density Microelectrode Array across Hundreds of Sites", Nature Communications, 2013, 4:2181 (DOI: 10.1038/ncomms3181). external page Online
Sara Rigante, Paolo Livi, Alexandru Rusu, Yihui Chen, Antonios Bazigos, Andreas Hierlemann, Adrian M. Ionescu, "FinFET Integrated Low-Power Circuits for Enhanced Sensing Applications", Sensors and Actuators B: Chemical, 2013, 186, pp. 789–795 (DOI: 10.1016/j.snb.2013.06.031). external page Online
Jan Müller, Douglas Bakkum and Andreas Hierlemann, "Sub-millisecond closed-loop feedback stimulation between arbitrary sets of individual neurons", Frontiers in Neural Circuits, 2013, 6:121 (DOI: 10.3389/fncir.2012.00121). external page Online
Simon Kemmerling, Stefan A. Arnold, Benjamin A. Bircher, Nora Sauter, Carlos Escobedo, Gregor Dernick, Andreas Hierlemann, Henning Stahlberg, Thomas Braun, "Single-cell lysis for visual analysis by electron microscopy", Journal of Structural Biology, 2013, 183 (3), pp. 467–473 (DOI: 10.1016/j.jsb.2013.06.012). external page Online
Paolo Livi, Kristine Bedner, Alexey Tarasov, Mathias Wipf, Yihui Chen, Christian Schönenberger, Andreas Hierlemann, "A Verilog-A model for silicon nanowire biosensors: from theory to verification", Sensors and Actuators B: Chemical, 2013, Vol. 179. pp. 293-300 (DOI: 10.1016/j.snb.2012.09.026). external page Online
2012
Felix Franke, David Jäckel, Jelena Dragas, Jan Müller, Milos Radivojevic, Douglas Bakkum and Andreas Hierlemann, "High-density microelectrode array recordings and real-time spike sorting for closed-loop experiments: an emerging technology to study neural plasticity", Frontiers in Neural Circuits, 2012, 6:105 (DOI: 10.3389/fncir.2012.00105). external page Online
Michele Fiscella, Karl Farrow, Ian L. Jones, David Jäckel, Jan Müller, Urs Frey, Douglas J. Bakkum, Péter Hantz, Botond Roska, Andreas Hierlemann, "Recording from defined populations of retinal ganglion cells using a high-density CMOS-integrated microelectrode array with real-time switchable electrode selection", Journal of Neuroscience Methods, 2012, Volume 211, Issue 1, pp. 103–113 (DOI: 10.1016/j.jneumeth.2012.08.017). external page Online
Zhen Zhu, Olivier Frey, Diana Silvia Ottoz, Fabian Rudolf, Andreas Hierlemann, "Microfluidic single-cell cultivation chip with controllable immobilization and selective release of yeast cells", Lab on a Chip, 2012, 12, 906-915 (DOI: 10.1039/c2lc20911j). external page Online
Simon Kemmerling, Jörg Ziegler, Gabriel Schweighauser, Stefan A. Arnold, Dominic Giss, Shirley A. Müller, Philippe Ringler, Kenneth N. Goldie, Nils Goedecke, Andreas Hierlemann, Henning Stahlberg, Andreas Engel, Thomas Braun, "Connecting μ-fluidics to electron microscopy", Journal of Structural Biology, 2012, Vol. 177, pp. 128–134 (DOI: 10.1016/j.jsb.2011.11.001). external page Online
David Jäckel, Urs Frey, Michele Fiscella, Felix Franke and Andreas Hierlemann, "Applicability of Independent Component Analysis on High-Density Microelectrode Array Recordings", Journal of Neurophysiology, 2012, 108 (1), pp. 334-348 (DOI: 10.1152/jn.01106.2011). external page Online
2011
J. Rothe, M. K. Lewandowska, F. Heer, O. Frey and A. Hierlemann, "Multi-target electrochemical biosensing enabled by integrated CMOS electronics", Journal of Micromechanics and Microengineering, 2011, 21(5), p. 054010 (DOI: 10.1088/0960-1317/21/5/054010. external page Online
A. Hierlemann, U. Frey, S. Hafizovic, F. Heer, "Growing Cells atop Microelectronic Chips: Interfacing Electrogenic Cells in Vitro with CMOS-based Microelectrode Arrays", Proceedings of the IEEE, 2011, Vol. 99, No. 2, pp. 252-284 (DOI: 10.1109/JPROC.2010.2066532). external page Online
Ian L. Jones, Paolo Livi, Marta K. Lewandowska, Michele Fiscella, Branka Roscic and Andreas Hierlemann, "The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics", Analytical and Bioanalytical Chemistry, 2011, Volume 399 (7), 2313-2329 (DOI: 10.1007/s00216-010-3968-1). external page Online
S.B. Truax, K.S. Demirci, L.A. Beardslee, Y. Luzinova, A. Hierlemann, B. Mizaikoff, O. Brand, "Mass-Sensitive Detection of Gas-Phase Volatile Organics Using Disk Microresonators", Analytical Chemistry, 2011, 83 (9), pp. 3305-3311 (DOI: 10.1021/ac1029902). external page Online
2010
U. Frey, J. Sedivy, F. Heer, R. Pedron, M. Ballini, J. Mueller, D. Bakkum, S. Hafizovic, F. D. Faraci, F. Greve, K.-U. Kirstein, and A. Hierlemann, "Switch-matrix-based high-density microelectrode array in CMOS technology", IEEE Journal of Solid-State Circuits, Vol. 45, no. 2, pp. 467–482, 2010 (DOI: 10.1109/JSSC.2009.2035196). external page Online
Ricardo Gutierrez-Osuna and Andreas Hierlemann, "Adaptive Microsensor Systems", Annu. Rev. Anal. Chem., Vol. 3, pp 255–76, 2010 (DOI: 10.1146/annurev.anchem.111808.073620). external page Online
A. Perera, A. Pardo, D. Barrettino, A. Hierlemann, S. Marco, "Evaluation of fish spoilage by means of a single metal oxide sensor under temperature modulation", Sensors and Actuators B, Chemical, 2010, 146, 477-482 (DOI: 10.1016/j.snb.2009.11.037). external page Online
Paolo Livi, Flavio Heer, Urs Frey, Douglas J. Bakkum, Andreas Hierlemann, "Compact Voltage and Current Stimulation Buffer for High-Density Microelectrode Arrays", IEEE Transactions on Biomedical Circuits and Systems, Vol. 4, No. 6, 2010, pp. 372-378 (DOI: 10.1109/TBCAS.2010.2080676). external page Online
2009
Petra Kurzawski, Volker Schurig and Andreas Hierlemann, "Chiral Sensing Using a Complementary Metal−Oxide Semiconductor-Integrated Three-Transducer Microsensor System", Analytical Chemistry, 2009, 81 (22), pp. 9353–9364 (DOI: 10.1021/ac9017007). external page Online
U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, "Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices", Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009 (DOI: 10.1016/j.bios.2008.11.028). external page Online
Petra Kurzawski, Anja Bogdanski, Volker Schurig, Reinhard Wimmer and Andreas Hierlemann, "Direct Determination of the Enantiomeric Purity or Enantiomeric Composition of Methylpropionates Using a Single Capacitive Microsensor", Analytical Chemistry, vol. 81, no. 5, pp 1969–1975, 2009 (DOI: 10.1021/ac802455c). external page Online
Wilfried Weber, Stefan Luzi, Maria Karlsson, Carlota Diaz Sanchez-Bustamante, Urs Frey, Andreas Hierlemann, and Martin Fussenegger, "A synthetic mammalian electro-genetic transcription circuit", Nucleic Acids Research, vol. 37, no. 4, pp. e33, 2009 (DOI: 10.1093/nar/gkp014). external page Online
A. Hierlemann, P. Kurzawski, V. Schurig, "The use of different transduction principles for qualitative and quantitative chiral gas analysis", ECS Transactions, 19 (6), 227-239, 2009 (DOI: 10.1149/1.3118556). external page Online
2008
P. Kurzawski, A. Bogdanski, V. Schurig, R. Wimmer, A. Hierlemann, "Opposite signs of capacitive microsensor signals upon exposure to the enantiomers of methyl propionates", Angew. Chem., International Edition, 2008, 47, 913-916 (DOI: 10.1002/anie.200704346). external page Online
A. Hierlemann, R. Gutierrez-Osuna, "Higher-order Chemical Sensing", Chemical Reviews, 2008, 108, 563-613 (DOI: 10.1021/cr068116m). external page Online
Antonio Tricoli, Markus Graf, Felix Mayer, Stéphane Kühne, Andreas Hierlemann and Sotiris E. Pratsinis, "Micropatterning Layers by Flame Aerosol Deposition - Annealing", Advanced Materials, 2008, 20, 3005-3010 (DOI: 10.1002/adma.200701844). external page Online
Stéphane Kühne, Markus Graf, Antonio Tricoli, Felix Mayer, Sotiris E. Pratsinis, Andreas Hierlemann, "Wafer-level flame-spray-pyrolysis deposition of gas-sensitive layers on microsensors", Journal of Micromechanics and Microengineering, 2008, 18, Article 035040 (DOI: 10.1088/0960-1317/18/3/035040). external page Online
Chunguang Jin, Petra Kurzawski, Andreas Hierlemann, and Edward T. Zellers, "Evaluation of Multi-Transducer Arrays for the Determination of Organic Vapor Mixtures", Anal. Chem., 2008, 80, 227-236 (DOI: 10.1021/ac0715120). external page Online
Cyril Vančura, Isabelle Dufour, Stephen M. Heinrich, Fabien Josse, and Andreas Hierlemann, "Analysis of Resonating Microcantilevers Operating in a Viscous Liquid Environment", Sensors and Actuators A, Physical, 2008, 141, 43-51 (DOI: 10.1016/j.sna.2007.07.010). external page Online
M. Zimmermann, T. Volden, K.-U. Kirstein, S. Hafizovic, J. Lichtenberg, Oliver Brand, and A. Hierlemann, "A CMOS-Based Integrated-System Architecture for a Static Cantilever Array", Sensors & Actuators: B. Chemical, 2008, 131, 254-264 (DOI: 10.1016/j.snb.2007.11.016). external page Online
C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger, "Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression", Tissue Engineering Part A, 2008, 14(12), 1969-1988 (DOI: 10.1089/ten.tea.2007.0302). external page Online
Yue Li, Cyril Vancura, Kai-Uwe Kirstein, Jan Lichtenberg, Andreas Hierlemann, "Monolithic Resonant cantilever-based CMOS Microsystem for Biochemical Sensing" , IEEE Transactions on Circuits and Systems I: Regular Papers, 2008, Volume 55, Issue 9, 2551 - 2560 (DOI: 10.1109/TCSI.2008.922027). external page Online
2007
U. Frey, M. Graf, S. Taschini, K.-U. Kirstein, A. Hierlemann, "A digital CMOS architecture for a micro-hotplate array", IEEE Journal of Solid-State Circuits, Vol. 42, No. 2, February 2007, p. 441-450 (DOI: 10.1109/JSSC.2006.889367). external page Online
D. Barrettino, P. Malcovati, M. Graf, S. Hafizovic, A. Hierlemann, "CMOS-based monolithic controllers for smart sensors comprising micromembranes and microcantilevers", IEEE Transactions on Circuits and Systems – 1: Regular Papers, Vol. 54. No. 1, January 2007, p. 141-152 (DOI: 10.1109/TCSI.2006.887457). external page Online
W. Franks, S. Tosatti, F. Heer, P. Seif, M. Textor, A. Hierlemann, "Patterned cell adhesion by self-assembled structures for use with a CMOS cell-based biosensor", Biosensors and Bioelectronics, 22 (2007), p. 1426-1433 (DOI: 10.1016/j.bios.2006.06.031). external page Online
F. Heer, S. Hafizovic, T. Ugniwenko, U. Frey, W. Franks, E. Perriard, J.-C. Perriard, A. Blau, C. Ziegler, A. Hierlemann, "Single-chip microelectronic system to interface with living cells", Biosensors and Bioelectronics, 22 (2007), p. 2546-2553 (DOI: 10.1016/j.bios.2006.10.003). external page Online
F. Greve, J. Lichtenberg, K.-U. Kirstein, U. Frey, J.-C. Perriard, A. Hierlemann, "A perforated CMOS microchip for immobilization and activity monitoring of electrogenic cells", Journal of Micromechanics and Microengineering, 17 (2007) p. 4562-471 (DOI: 10.1088/0960-1317/17/3/007). external page Online
C. Vancura, Y. Li, J. Lichtenberg, K.-U. Kirstein, A. Hierlemann, "Liquid-phase chemical and biochemical detection using fully integrated magnetically actuated complementary metal oxide semiconductor resonant cantilever sensor systems", Analytical Chemistry, Vol. 78, No. 4 (2007), p. 1646-1654 (DOI: 10.1021/ac061795g). external page Online
S. Hafizovic, F. Heer, T. Ugniwenko, U. Frey, A. Blau, C. Ziegler, A. Hierlemann, "A CMOS-based microelectrode array for interaction with neuronal cultures", Journal of Neuroscience Methods, Vol. 164 (2007), p. 93-106 (DOI://
doi:10.1016/j.jneumeth.2007.04.006). external page Online
O. Frey, S. Bonneick, A. Hierlemann, J. Lichtenberg, "Autonomous microfluidic multi-channel chip for real-time PCR with integrated liquid handling", Biomedical Microdevices, 9 (2007) p. 711-718 (DOI: 10.1007/s10544-007-9080-4). external page Online
F. Greve, L. Seemann, A. Hierlemann, J. Lichtenberg, "A hybrid microsystem for parallel perfusion experiments on living cells", Journal of Micromechnics and Microengineering, Vol. 17 (2007) 1721-1730 (DOI: 10.1088/0960-1317/17/8/040). external page Online
Y. Li, C. Vancura, D. Barrettino, M. Graf, C. Hagleitner, A. Kummer, M. Zimmermann, K.-U. Kirstein, A. Hierlemann, "Monolithic CMOS multi-transducer gas sensor microsystem for organic and inorganic analytes", Sensors and Actuators B, Vol. 126 (2007) 431-440 (DOI: 10.1016/j.snb.2007.03.035). external page Online
F. Greve, S. Frerker, A.G. Bittermann, C. Burkhardt, A. Hierlemann, H. Hall, "Molecular design and characterization of the neuron-microelectrode array interface", Biomaterials, 28 (2007) p. 5246-5258 (DOI: 10.1016/j.biomaterials.2007.08.010). external page Online
2006
A. Kummer, A. Hierlemann, "Configurable electrodes for capacitive-type sensors and chemical sensors", IEEE Sensors Journal, Vol. 6, No. 1, February 2006, pp 3-10 (DOI: 10.1109/JSEN.2005.856547). external page Online
A. Kummer, T. Burg, A. Hierlemann, "Transient signal analysis using complementary metal oxide semiconductor capacitive chemical microsensors", Analytical Chemistry, Vol. 78, No. 1, January 2006, pp 279-290 (DOI: 10.1021/ac051430g). external page Online
T. Kraus, E. Verpoorte, V. Linder, W. Franks, A. Hierlemann, F. Heer, S. Hafizovic, T. Fujii, N. de Rooij, S. Koster, "Characterization of a microfluidic dispensing sytem for localised stimulation of cellular networks", Lab Chip, 6, 2006, pp 218-229 (DOI: 10.1039/b511768b). external page Online
D. Barrettino, M. Graf, S. Taschini, S. Hafizovic, C. Hagleitner, A. Hierlemann, "CMOS monolithic metal-oxide gas sensor microsystems", IEEE Sensor Journal, Vol. 6, No. 2, 2006, pp. 276-286 (DOI: 10.1039/b511768b). external page Online
V. Linder, S. Koster, W. Franks, T. Kraus, E. Verpoorte, F. Heer, A. Hierlemann, N.F. de Rooij, "Microfluidics/CMOS orthogonal capabiliies for cell biology", Biomedical Microdevices, 8 (2006) 159-166 (DOI: 10.1007/s10544-006-7711-9). external page Online
F. Heer, S. Hafizovic, W. Franks, A. Blau, C. Ziegler, A. Hierlemann, "CMOS microelectrode array for bidirectional interaction with neuronal networks", IEEE Journal of Solid-State Circuits, Vol. 41, No. 7 (2006) 1620-1629 (DOI: 10.1109/JSSC.2006.873677). external page Online
P. Kurzawski, T. Salo, H. Baltes, A. Hierlemann, "Towards a versatile DRIE: Silicon Pit structures combined with electrochemical etch Stop", Journal of Microelectromechanical Systems, Vol. 15, No. 4 (2006) 840-848 (DOI: 10.1109/JMEMS.2006.878883). external page Online
M. Graf, U. Frey, S. Taschini, A. Hierlemann, "Micro hot plate-based sensor array system for the detection of environmentally relevant gases", Analytical Chemistry, Vol. 78, No. 19 (2006) 6801-6808 (DOI: 10.1021/ac060467d). external page Online
P. Kurzawski, C. Hagleitner, A. Hierlemann, "Detection and discrimination capabilities of a multitransducer single-chip gas sensor system", Analytical Chemistry, Vol. 78, No. 19 (2006) 6910-6920 (DOI: 10.1021/ac0610107). external page Online
M. Graf, D. Barrettino, K.-U. Kirstein, A. Hierlemann, "CMOS microhotplate sensor system for operating temperatures up to 550°C", Sensors and Actuators B, 117 (2006) 346-352 (DOI: 10.1016/j.snb.2005.11.012). external page Online
J.M. Kelm, V. Djonov, S.P. Hoerstrup,, C.I. Guenter, L.M. Ittner, F. Greve, A. Hierlemann, C.D. Sanchez-Bustamante, J.-C. Perriard, E. Ehler, M. Fussenegger, "Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats", Tissue Engineering, Vol. 12, No. 9 (2006) 1 – 13.
Received the 2006 ESAO (European Society of Artificial Organs) Research Award (DOI: 10.1089/ten.2006.12.2541). external page Online
G. Romera-Guereca, J. Lichtenberg, A. Hierlemann, D. Poulikakos, B. Kang, "Explosive vaporization in microenclosures", Experimental Thermal and Fluid Science, 30 (2006) 829-836 (DOI: 10.1016/j.expthermflusci.2006.03.012). external page Online
M. Graf, A. Gurlo, N. Barsan, U. Weimar, A. Hierlemann, "Microfabricated gas sensor system with sensitive nanocrystalline metal-oxide films", Journal of Nanoparticle Research, 8 (2006) 823-839 (DOI: 10.1007/s11051-005-9036-7). external page Online
2005
M. Graf, R. Jurischka, D. Barrettino, and A. Hierlemann, "3-D nonlinear modelling of microhotplates in CMOS technology for use as metal-oxide-based gas sensors", Journal of Micromechanics and Microengineering, 15 (2005) 190-200 (DOI: 10.1088/0960-1317/15/1/027). external page Online
D. Barrettino, S. Hafizovic, T. Volden, J. Sedivy, K.-U. Kirstein, A. Hierlemann, "CMOS monolithic mechatronic microsystem for surface imaging and force response studies", IEEE Journal of Solid-State Circuits, 40 (2005) 951-959 (DOI:
10.1109/JSSC.2004.842868). external page Online
M. Graf, S.K. Müller, D. Barrettino, A. Hierlemann,"Transistor heater for microhotplate-based metal-oxide microsensors", IEEE Electron Device Letters, 26 (2005) 295-297 (DOI: 10.1109/LED.2005.846899). external page Online
C. Vancura, M. Rüegg, Y. Li, C. Hagleitner, A. Hierlemann, "Magnetically actuated complementary metal oxide semiconductor resonant cantilever gas sensor systems", Analytical Chemistry, 77 (2005) 2690-2699 (DOI: 10.1021/ac048378t). external page Online
W. Franks, I. Schenker, P. Schmutz, A. Hierlemann, "Impedance characterization and modeling of electrodes for biomedical applications", IEEE Transactions on Biomedical Engineering, 52 (2005) 1295-1302 (DOI: 10.1109/TBME.2005.847523). external page Online
C. Vancura, J. Lichtenberg, A. Hierlemann, "Characterization of magnetically actuated resonant cantilevers in viscous fluids", Applied Physics Letters, 87, (2005) 87-89 (DOI: 10.1063/1.2108130). external page Online
T. Bechtold. E- B. Rudnyi, J.G. Korvink, M. Graf, A. Hierlemann, "Connecting heat transfer macromodels for array MEMS structures", Journal of Micromechanics and Microengineering, 15 (2005) 1205-1214 (DOI: 10.1088/0960-1317/15/6/010). external page Online
A. Hierlemann, "Integrated chemical microsensor systems in CMOS technology", LabPlus international, Vol. 19, No. 4, Sept. 2005, 14-18 (DOI: 10.1109/SENSOR.2005.1497276). external page Online
2004
S. Hafizovic, D. Barrettino, T. Volden, J. Sedivy, K.-U. Kirstein, O. Brand, A. Hierlemann, "Single-chip mechatronic microsystem for surface imaging and force response studies", PNAS, Vol. 101, No. 49 (2004) 17011-17015 *(DOI: 10.1073/pnas.0405725101). external page Online
M. Graf, D. Barrettino, M. Zimmermann, A. Hierlemann, H. Baltes, S. Hahn, N. Bârsan, U. Weimar, "CMOS monolithic metal-oxide sensor system comprising a microhotplate and associated circuitry", IEEE Sensor Journal, Vol. 4 (2004) 9-16 (DOI:
10.1109/JSEN.2003.820367). external page Online
A. Kummer, A. Hierlemann, H. Baltes, "Tuning Sensitivity and Selectivity of complementary metal oxide semiconductor-based capacitive chemical microsensors", Analytical Chemistry, 76 (2004) 2470-2477 (DOI: 10.1021/ac0352272). external page Online
M. Graf, D. Barrettino, S. Taschini, C. Hagleitner, A. Hierlemann, H. Baltes, "Metal oxide-based monolithic complementary metal oxide semiconductor gas sensor microsystem", Analytical Chemistry, 76 (2004) 4437-4445 (DOI: 10.1021/ac035432h). external page Online
D. Barrettino, M. Graf, M. Zimmermann, C. Hagleitner, A. Hierlemann, H. Baltes, "A smart single-chip micro-hotplate-based gase sensor system in CMOS-technology", Int. Journal on Analog Integrated Circuits and Signal Processing, 39 (2004) 275-287 (DOI: 10.1109/ISCAS.2002.1010948). external page Online
F. Heer, W. Franks, A. Blau, S. Taschini, C. Ziegler, A. Hierlemann, H. Baltes, "CMOS microelectrode array for the monitoring of electrogenic cells", Biosensors & Bioelectronics, 20 (2004) 358-366 (DOI: 10.1016/j.bios.2004.02.006). external page Online
M. Jenkner, M. Tartagni, A. Hierlemann, and R. Thewes, "Cell-Based CMOS Sensor and Actuator Arrays", IEEE Journal of Solid-State Circuits, Vol. 39, No. 12 (2004) 24312437 (DOI: 10.1109/JSSC.2004.837082). external page Online
2003
A. Hierlemann, O. Brand, C. Hagleitner, H. Baltes, "Microfabrication techniques for chemical/biosensors", Proceedings of the IEEE, 91 (6), 2003, 839-863. ISSN 0018-9219 (DOI: 10.1109/JPROC.2003.813583). external page Online
A. Hierlemann, H. Baltes, "CMOS-based chemical microsensors", The Analyst, 128 (1), 2003, pp. 15-28 (DOI: 10.1039/B208563C). external page Online
2002
W. Franks, D. Lange, S. Lee, A. Hierlemann, N. Spencer, H. Baltes, "Nanochemical surface analyzer in CMOS technology", Ultramicroscopy, 91 (1-4), 2002, 21 - 27. ISSN 0304-3991 (DOI: 10.1016/S0304-3991(02)00078-5). external page Online
D. Lange, C. Hagleitner, A. Hierlemann, O. Brand, H. Baltes, "Complementary Metal Oxide Semiconductor Cantilever Arrays on a Single Chip: Mass-Sensitive Detection of Volatile Organic Compounds", Analytical Chemistry, 2002, 74 (13). pp. 3084-3095 (DOI: 10.1021/ac011269j). external page Online
2001
C. Hagleitner, A. Hierlemann, D. Lange, A. Kummer, N. Kerness, O. Brand, H. Baltes, "Smart single-chip gas sensor microsystem", Nature, 414 (6861), 2001, p. 293. (DOI: 10.1038/35104535). external page Online
A. Hierlemann,H. Baltes, V. Schurig, "Search for extraterrestrial enantioenrichment by using chemical microsensors", Enantiomer, 6 (2-3), 2001, pp. 129-139. ISSN 1024-2430. external page Online
A. Hierlemann, E.T. Zellers, A.J. Ricco, "Use of Linear Solvation Energy Relationships for Modeling Responses from Polymer-Coated Acoustic-Wave Vapor Sensors", Analytical Chemistry, 73 (14), 2001, pp. 3458-3466 (DOI: 10.1021/ac010083h). external page Online
2000
A. Hierlemann, A.J. Ricco, K. Bodenhöfer, A. Dominik, W. Göpel, "Conferring Selectivity to Chemical Sensors via Polymer Side-Chain Selection: Thermodynamics of Vapor Sorption by a Set of Polysiloxanes on Thickness-Shear Mode Resonators", Anal Chem., 72 (2000) 3696-3708 (DOI: 10.1021/ac991298i). external page Online
A. Hierlemann, A. Koll, D.Lange, C. Hagleitner, N. Kerness, O. Brand, H. Baltes, "Application-Specific Sensor Systems Based on CMOS Chemical Microsensors", Sensors and Actuators B, 70 (2000) 2-11 (DOI: 10.1016/S0925-4005(00)00546-3). external page Online
Before 2000
A. Hierlemann, A.J. Ricco, K. Bodenhöfer, W. Göpel, "Effective Use of Molecular Recognition in Gas Sensing: Results from Acoustic Wave and In-Situ FTIR Measurements", Anal. Chem., 71 (1999) 3022-3035 (DOI: 10.1021/ac981311j). external page Online
A. Hierlemann, K. Bodenhöfer, M. Juza, B. Gross, V. Schurig, W. Göpel, "Enantioselective Monitoring of Chiral Inhalation Anesthetics by Simple Gas Sensors", Sensors and Materials, 11, 4 (1999) 209-218. ISSN: 0914-4935. external page Online
R.C. Thomas, A. Hierlemann, A.W. Staton, M. Hill, and A.J. Ricco, "Reflectance Infrared Spectroscopy on Operating Surface Acoustic Wave Chemical Sensors during Exposure to Gas-Phase Analytes", Anal. Chem., 71 (1999) 3615-3621 (DOI: 10.1021/ac981447h). external page Online
A. Hierlemann, J.C. Campbell, L. Baker, R.M. Crooks, A.J. Ricco, "Structural Distortion of Dendrimers on Gold Surfaces: A Tapping-Mode AFM Investigation", J. Am. Chem. Soc., 120 (1998) 5323-5324 (DOI: 10.1021/ja974283f). external page Online
K. Bodenhöfer, A. Hierlemann, W. Göpel, M. Juza, B. Gross and V. Schurig, "Efficient Gas Sensor Mediated Enantiomer Discrimination of 2-Substituted Methyl Propionates and Chiral Inhalation Anaesthetics on a Modified Cyclodextrin", Chimica OGGI-Chemistry Today, 16 (1998) 56-58l, ISBN: 0392-839X. external page Online
K. Bodenhöfer, A. Hierlemann, J. Seemann, G. Gauglitz, B. Koppenhoefer, W. Göpel, "Chiral Discrimination using Piezoelectric and Optical Gas Sensors", Nature, 387 (1997) 577-580 (DOI: 10.1038/42426). external page Online
K. Bodenhöfer, A. Hierlemann, J. Seemann, G. Gauglitz, W. Göpel, "Chiral Discrimination in the Gas Phase Using Different Transducers: Thickness Shear Mode Resonators and Reflectometric Interference Spectroscopy", Anal. Chem., 69 (1997) 3058-3068 (DOI: 10.1021/ac9612990). external page Online
K. Bodenhöfer, A. Hierlemann, R. Schlunk, and W. Göpel, "New Method of Vaporising Volatile Organics for Gas Tests", Sens. Actuators B, 45/3 (1997) 259-264 (DOI: 10.1016/S0925-4005(97)00319-5). external page Online
K. Bodenhöfer, A. Hierlemann, M. Juza, V. Schurig, W. Göpel, "Chiral Discrimination of Inhalation Anesthetics and Methyl Propionates by Thickness Shear Mode Resonators: New Insights into the Mechanisms of Enantioselectivity by Cyclodextrins", Anal. Chem., 69 (1997) 4017-4031 (DOI: 10.1021/ac970367v). external page Online
R. Zhou, A. Hierlemann, U. Weimar, W. Göpel, "Gravimetric, Dielectric and Calorimetric Methods for the Detection of Organic Solvent Vapours Using Polyetherurethane Coatings", Sens. Actuators B, 34 (1996) 356 (DOI: 10.1016/S0925-4005(96)01912-0). external page Online
Marco, A. Pardo, F. Davide, C. DiNatale, A. D'Amico, A. Hierlemann, W. Göpel, "Different Strategies for the Dynamic Calibration of Gas Sensors", Sens. Actuators B, 34 (1996) 213-223 (DOI: 10.1016/S0925-4005(97)80001-9). external page Online
A. Hierlemann, K. Bodenhöfer, M. Fluck, V. Schurig, W. Göpel, "Selective Detection of Nitrogen- and Oxygen-Containing Analytes Using Metal-Modified Polysiloxanes as sensor coatings", Anal. Chim. Acta, 346 (1997) 327-339 (DOI: 10.1016/S0003-2670(97)90073-8). external page Online
A. Hierlemann, K. Bodenhöfer, G. Noetzel, U. Weimar, W. Göpel, "Performances of Mass-Sensitive Devices for Gas Sensing: Thickness Shear Mode and Surface Acoustic Wave Transducers", Anal. Chem., 68 (1996) 2210-2218 (DOI: 10.1021/ac9600215). external page Online
R. Zhou, A. Hierlemann, K.D. Schierbaum, K.E. Geckeler, W. Göpel, "Detection of Organic Solvents with Reliable Chemical Sensors Based on Cellulose Derivatives", Sens. Actuators B, 24-25 (1995) 443-447 (DOI: 10.1016/0925-4005(95)85099-6). external page Online
C. DiNatale, F. Davide, A. D'Amico, A. Hierlemann, J. Mitrovics, M. Schweizer, U. Weimar, W. Göpel, "A composed neural net for the recognition of gas mixtures", Sens. Actuators B, 24-25 (1995) 808-812 (DOI: 10.1016/0925-4005(95)85180-1). external page Online
F.A.M. Davide, C. DiNatale, A. D'Amico, A. Hierlemann, J. Mitrovics, M. Schweizer, U. Weimar, W. Göpel, "Structure Identification of Nonlinear Models for QMB Polymer-Coated Sensors", Sens. Actuators B, 24-25 (1995) 830-842 (DOI: 10.1016/0925-4005(95)85185-2). external page Online
C. Cornila, A. Hierlemann, R. Lenggenhager, P. Malcovati, H. Baltes, G. Noetzel, U. Weimar, W. Göpel, "Capacitive Sensors in CMOS Technology with Polymer Coating", Sens. Actuators B, 24-25 (1995) 357-361 (DOI: 10.1016/0925-4005(95)85080-5). external page Online
A. Hierlemann, U. Weimar, G. Kraus, G. Gauglitz, W. Göpel, "Environmental Chemical Sensing Using Quartz Microbalance Sensor Arrays: Application of Multicomponent Analysis Techniques", Sens. Materials, 7 (3) (1995) 179-189, ISSN: 0914-4935. external page Online
J.W. Gardner, A. Pike, N. F. de Rooij, M. Koudelka-Hep, P. Clerc, A. Hierlemann, W. Göpel, "Integrated Array Sensor for Detecting Organic Solvents", Sens. Actuators B, 26-27 (1995) 135-139 (DOI: 10.1016/0925-4005(94)01573-Z). external page Online
F.A.M. Davide, C. DiNatale, A. D'Amico, A. Hierlemann, J. Mitrovics, M. Schweizer, U. Weimar, W. Göpel, S. Marco, A. Pardo, "Dynamic Calibration of QMB Polymer-Coated Sensors by Wiener Kernel Estimation", Sens. Actuators B, 26-27 (1995) 275-285 (DOI: 10.1016/0925-4005(94)01601-D). external page Online
M. Schweizer, J. Göppert, A. Hierlemann, J. Mitrovics, U. Weimar, W. Rosenstiel, W. Göpel, "Application of Neural Network Systems to the Dynamic Response of Polymer-Based Sensor Arrays", Sens. Actuators B, 26-27 (1995) 232-236 (DOI: 10.1016/0925-4005(94)01592-6). external page Online
A. Hierlemann, U. Weimar, G. Kraus, M. Schweizer, W. Göpel, "Polymer-Based Sensor Arrays and Multicomponent Analysis for the Detection of Hazardous Organic Vapours in the Environment", Sens. Actuators B, 26-27 (1995) 126-134, (DOI: 10.1016/0925-4005(94)01572-4). external page Online
K.D. Schierbaum, A. Hierlemann, W.Göpel, "Modified Polymers for Reliable Detection of Organic Solvents", Sens. Actuators B, 18-19 (1994) 448-452, (DOI: 10.1016/0925-4005(93)01034-2). external page Online