Publications

external page Efficient synthesis of 2,6.bis(hydroxymethyl)pyridine using whole-​cell biocatalysis. Kardashliev, T., Panke, S., & M. Held. Green Chem. (2022). 

external page Optimization of the antimicrobial peptide Bac7 by deep mutational scanning. Koch, P., Schmitt, S., Heynisch, A., Gumpinger, A., Wüthrich, I., Gysin, M., Shcherbakov, D., Hobbie, S. N., Panke, S., & M. Held. BMC Biol. (2022).

external page A multiplexed cell-free assay to screen for antimicrobial peptides in double emulsion droplets. Nuti, N.¹, Rottmann, P.¹, Stucki, A., Koch, P., Panke, S., & P. S. Dittrich. Angew. Chem. Int. (2022).

external page Directed evolution of biofuel-responsive biosensors for automated optimization of branched-chain alcohol biosynthesis. Bahls, M., Platz, L., Morgado, G., Schmidt, G. W., & S. Panke. Metabol. Eng. (2022).

external page Whole-cell screening of oxidative enzymes using genetically encoded sensors. Kardashliev, T., Weingartner, A., Romero, E., Schwaneberg, U., Fraaije, M., Panke, S., and M. Held. Chem. Sc. (2021).

external page Acoustofluidic medium exchange for preparation of electrocompetent bacteria using channel wall trapping. Gerlt, M. S., Ruppen, P., Leuthner, M., Panke, S., and J. Dual. Lab Chip (2021).

external page Plasmid replication based on the T7 origin of replication requires a T7 RNAP variant and inactivation of ribonuclease H  K Becker,  A Meyer, TM Roberts, S Panke. Nucleic Acids Research (2021).

external page Systematic engineering of artificial metalloenzymes for new-to-nature reactions. T Vornholt , F Christoffel, MM Pellizzoni, S Panke, TR Ward, M Jeschek. Science Advances (2021).  

external page High-Throughput Optimization of Recombinant Protein Production in Microfluidic Gel Beads M Napiorkowska, L Pestalozzi, S Panke, M Held, S Schmitt. Small (2021).

external page Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping. S. Höllerer, L. Papaxanthos, A.C. Gumpinger, K. Fischer, C. Beisel, K. Borgwardt, Y. Benenson & M. Jeschek. Nature Communications (2020).

external page Ultra-high throughput screening for novel protease specificities. E. Rousounelou, S. Schmitt, L. Pestalozzi, M. Held, T.M. Roberts & S. Panke. Methods in Enzymology (2020).

external page The Quest for Xenobiotic Enzymes: From New Enzymes for Chemistry to a Novel Chemistry of Life. T. Vornholt & M. Jeschek. ChemBioChem (2020).

external page Semi-rational engineering of an amino acid racemase that is stabilized in aqueous/organic solvent mixtures. C. Femmer, M. Bechtold & S. Panke. Biotechnology and Bioengineering (2020).

external page In vivo directed enzyme evolution in nanoliter reactors with antimetabolite selection. C. Femmer, M. Bechtold, M. Held & S. Panke. Metabolic Engineering (2020).

external page Taming the Beast of Biology: Synthetic Biology and Biological Systems Engineering. S. Panke. CHIMIA International Journal for Chemistry (2020).

external page Development and optimisation of a defined high cell density yeast medium. T.M. Roberts, H.-M. Kaltenbach & F. Rudolf. Yeast (2020).

external page Editorial overview: Beyond canonical biochemistry. S. Panke & T. Ward. Current Opinion in Biotechnology (2019).

external page Analysis of modular bioengineered antimicrobial lanthipeptides at nanoliter scale. S. Schmitt, M. Montalbán-López, D. Peterhoff, J. Deng, R. Wagner, M. Held, O.P. Kuipers & S. Panke. Nature Chemical Biology (2019).

external page Mutant variants of the substrate-binding protein DppA from Escherichia coli enhance growth on nonstandard γ-glutamyl amide-containing peptides. T. Kuenzl, X. Li-Blatter, P. Srivastava, P. Herdewijn, T. Sharpe & S. Panke. Applied and Environmental Microbiology (2018).

external page Identification and Characterisation of a pH-stable GFP. T.M. Roberts, F. Rudolf, A. Meyer, R. Pellaux, E. Whitehead, S. Panke & M. Held. Scientific Reports (2018).

external page Archimedes’ principle for characterisation of recombinant whole cell biocatalysts. S. Schmitt, M. Walser, M. Rehmann, S. Oesterle, S. Panke & M. Held. Scientific Reports (2018).

external page Sequence-based prediction of permissive stretches for internal protein tagging and knockdown. S. Oesterle, T. M. Roberts, L. A. Widmer, H. Mustafa, S. Panke & S. Billerbeck. BMC Biology (2017).

external page Overcoming the membrane barrier: Recruitment of γ-glutamyl transferase for intracellular release of metabolic cargo from peptide vectors. T. Kuenzl, M. Sroka, P. Srivastava, P. Herdewijn, P. Marlière & S. Panke. Metabolic Engineering (2017).

external page Forward design of a complex enzyme cascade reaction. C. Hold, S. Billerbeck & S. Panke. Nature Communications (2016).

external page Directed evolution of artificial metalloenzymes forin vivometathesis. M. Jeschek, R. Reuter, T. Heinisch, C. Trindler, J. Klehr, S. Panke & T.R. Ward. Nature (2016).

external page Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort. M. Jeschek, D. Gerngross & S. Panke. Nature Communications (2016).

RedLibs software

external page Optimization of a whole-cell biocatalyst by employing genetically encoded product sensors inside nanolitre reactors. A. Meyer, R. Pellaux, S. Potot, K. Becker, H.-P. Hohmann, S. Panke & M. Held. Nature Chemistry (2015).

external page A Separation-Integrated Cascade Reaction to Overcome Thermodynamic Limitations in Rare-Sugar Synthesis. N. Wagner, A. Bosshart, J. Failmezger, M. Bechtold & S. Panke. Angewandte Chemie - International Edition (2015).

external page Systematic optimization of interface interactions increases the thermostability of a multimeric enzyme. A. Bosshart, S. Panke & M. Bechtold. Angewandte Chemie - International Edition (2013).

external page The good of two worlds. Increasing complexity in cell-free systems. S. Billerbeck, J. Härle & S. Panke. Current Opinion in Biotechnology (2013).