Computational Methods

We develop computational methods for the modeling and simulation of signalling networks, cell-​based tissue simulations, image processing and image-​based modelling.  

Cell-based Tissue Simulation Framework

We have developed LBIBCell, PolyHoop and SimuCell3D (all C++-based) to simulate tissue development in 2D and 3D at cellular resolution.

SimuCell3D

SimuCell3D: 3D Simulation of Tissue Mechanics with Cell Polarization
Steve Runser, Roman Vetter, and Dagmar Iber
external page Nature Computational Science (2024), external page News & Viewsexternal page Tweetorial

PolyHoop

PolyHoop: Soft particle and tissue dynamics with topological transitions. 
Roman Vetter, Steve Runser, and Dagmar Iber
external page Computer Physics Communications (2024), external page Tweetorial

LBIBCell

LBIBCell: A Cell-Based Simulation Environment for Morphogenetic Problems.
Tanaka S, Sichau D, Iber D, external page Bioinformatics, 2015.

external page Documentationexternal page Download

 

MOCCASIN

external page MOCCASIN

We developed MOCCASIN to translate MATLAB ODE models into SBML.  

COMSOL

COMSOL
We are developing COMSOL applications for image-based modelling.