Welcome to the Quantitative Developmental Biology lab. We are an interdisciplinary team of researchers that are excited to apply novel, quantitative single-cell technologies to understand development and regeneration.

Every cell has a story to tell. New technologies to sequence RNA and DNA from individual cells are providing unprecedented insights into the biology of complex tissues. In parallel, it is now possible to grow three-dimensional human tissues in vitro (so-called “organoids”) that recapitulate human organ development.
We are using single-cell genomic, imaging, and computational tools to dissect human organoid formation and understand how processes fail in human disease. We are also working on new approaches to engineer organoid development to better match the real tissues, and enable them to mature in vitro.

Finally, we are also exploring other exciting biological systems in which cells undergo dynamic cell fate conversions, such as in amphibian appendages, direct human cell reprogramming, and any other systems we find fascinating!