New method to incorporate pathogen phylogeny in infectious disease GWAS published
Our method to correct host infectious disease genome-wide association studies for pathogen phylogenetic correlations is now published in Molecular Biology and Evolution!
The new method is based on a phylogenetic model that distinguishes between pathogen and host or environmental contributions to an infectious disease trait.
This study considers how to account for phylogenetic correlations due to related pathogen strains in infectious disease GWAS for host determinants of infectious disease traits. We present a new method to do this and apply it to HIV-1 virulence in humans and X. arboricola virulence in A. thaliana. We find previous GWAS results are robust to pathogen phylogenetic correlations in both systems.
You can read the full article external page here!