Personalized Swiss Sepsis Study

The Personalized Swiss Sepsis Study is a SPHN/PHRT driver project with the goal to build an interoperable infrastructure among the intensive care units of the Swiss university hospitals and several research groups, to gather complex information on the host and pathogen during the entire course of a sepsis. The integration of continuous monitoring data from intensive care units will result in digital biomarkers. Combined with the molecular data from bacterial pathogens (metagenomics and whole genome sequencing) and from the host (metabolomics, immunophenotyping, genotyping), new avenues for sepsis research will emerge. These very comprehensive and complex data will be combined via the SPHN data hubs to enable multi-dimensional analyses through machine learning. The goal is to recognize a bacterial sepsis earlier and to predict its course more precisely than currently possible for an individual patient.