A cholesterol analog stabilizes basally active conformations of the β2-adrenergic receptor
The latest work of Tetiana Serdiuk and colleagues from our laboratory has been published in Science Signaling.
Tetiana Serdiuk and colleagues from our laboratory show in their work that the cholesterol analog cholesteryl hemisuccinate (CHS) stabilizes basally active conformations of the β2-adrenergic receptor (β2AR) in membranes at physiological temperature. The image depicts the β2AR interacting with CHS (green surfaces) in liposomes at 37℃. More info at https://www.science.org/doi/10.1126/scisignal.abi7031