CSD News

Identification of an embryonic differentiation stage marked by Sox1 and FoxA2 co-expression using combined cell tracking and high dimensional protein imaging

On 1 September 2004, Timm started his independent group in Munich, Germany, which is now the ETH BSSE’s Cell Systems Dynamics group

aiSEGcell: user-friendly deep learning-based segmentation of nuclei in transmitted light images

Congrats Dr. Zhang

Aron, Benian, Daniel, David, Florin, German, Linus, Markus, Moritz, Timm, Yang

to our beautiful new building

Congratulations!

from the German Stem Cell Network (GSCN) for the International Society for Experimental Hematology annual meeting, USA

Optogenetic manipulation identifies the roles of ERK and AKT dynamics in controlling mouse embryonic stem cell exit from pluripotency

Embryonic stem cell ERK, AKT, plus STAT3 response dynamics combinatorics are heterogeneous but NANOG state independent

We’ll move in 2023

LeoDanKonstantinosTimm’s bone pic got the highest bid at the auction!

To develop a napari plug in for ‘Deep Learning-Based Segmentation for Bright Field Images’

Combined single-cell tracking and omics improves blood stem cell fate regulator identification

Eugene Cronkite Award - First prize for postdoctoral fellows by the International Society for Experimental Hematology (ISEH) 

from the International Society for Experimental Hematology (ISEH) and the German Stem Cell Network (GSCN) to present at the annual ISEH meeting in Edinburgh, Scotland

OptimaRatio help patients with complex diseases to find the right diagnosis and care based on their health history

NfκB signaling dynamics and their target genes differ between mouse blood cell types and induce distinct cell behavior

Open-​source personal pipetting robots with live-​cell incubation and microscopy compatibility

Congrats Dr. Arekatla

Congratulations Dr. Kokkaliaris!

Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation

Congratulations!

Congratulations Dr. Loeffler!    

‘Effector-target cell interactions in engineered immune-therapy against hematologic malignancies’ with Manz group from Zurich University Hospital.

Asymmetric organelle inheritance predicts human blood stem cell fate

Congrats Dr. Dettinger!

with Martin Kampmann at the annual meeting of the International Society of Stem Cell Research (ISSCR)

to present at the annual meeting of the International Society of Stem Cell Research (ISSCR)

Cytokine combinations for human blood stem cell expansion induce cell type- and cytokine-specific signaling dynamics

Congrats Dr. Wehling!

Congratulations Dr. Ahmed!

for Konstantinos' image of the bone marrow cellular architecture

Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations

Congratulations Dr. Kull!

An Automated Microfluidic System for Efficient Capture of Rare Cells and Rapid Flow-free Stimulation

George Brecher Award for postdoctoral fellows by the International Society for Experimental Hematology (ISEH)

A novel GATA2 protein reporter mouse reveals hematopoietic progenitor cell types

for Nature paper ‘Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells’

‘Patient specific signalling dynamics in myeloproliferative neoplasms as predictive biomarkers for outcome and responsiveness to treatment’ with Skoda group from Basel University.  

Congratulations!

A 3D tissue-​wide digital imaging pipeline for quantitation of secreted molecules shows absence of CXCL12 gradients in bone marrow

of the Helmholtz Center Munich. Congratulations!

Congratulations Dr. Reimann!

Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells

for his paper ‘The centrosome protein AKNA regulates neurogenesis via microtubule organization’, Nature 2019 Congratulations!

Congratulations!

Congratulations!

Congratulations Dr. Kunz!

to present at the annual meeting of the International Society for Experimental Hematology (ISEH) in Brisbane, Australia

from the the International Society for Experimental Hematology (ISEH) and the German Stem Cell Network (GSCN) to present at the annual ISEH meeting in Brisbane, Australia

to present at the annual meeting of the International Society for Experimental Hematology (ISEH) in Brisbane, Australia

Cell Systems Dynamics Group on joint retreat with Lausanne EPFL’s Radtke, Huelsken, Deplancke, Suter and Naveiras, Basel University’s Martin and Heidelberg DKFZ Esser groups

Congratulations!

Congratulations!

‘Elucidating the human mesenchymal bone marrow stromal hierarchy in health and disease’ with groups from EPFL and Zurich University.

Cell Systems Dynamics Group on joint retreat with Basel University group

in Ascona, Switzerland

Understanding Cell Fate Control by Continuous Single Cell Quantification

Inflammatory signals directly instruct PU.1 in HSCs via TNF

Congratulations!

in Colorado, USA

from Keystone Symposia to present at the Single Cell Biology Keystone meeting in Colorado, USA

for the Single Cell Biology meeting in Colorado, USA

Congratulations Dr. Hilsenbeck!

national Swiss prize for medical research by The Professor Dr Max Cloëtta Foundation

on Paul’s paper ‘In vitro biomimetic engineering of a human hematopoietic niche with functional properties’

from the German Stem Cell Network (GSCN) to present at the annual Berlin Summer Meeting in Germany

for Phil's image depicting the evolution of a microfluidic chip from conception to implementation

Congratulations Professor Bourgine!

Eugene Cronkite Award - First prize for postdoctoral fellows by the International Society for Experimental Hematology (ISEH) 

with his synthetic biology project "From Plastics to Biologics"

from the the International Society for Experimental Hematology (ISEH), SystemsX.ch and the German Stem Cell Network (GSCN) to present at the annual ISEH meeting in Los Angeles, USA

from the the International Society for Experimental Hematology (ISEH) and the German Stem Cell Network (GSCN) to present at the annual ISEH meeting in Los Angeles, USA

Automated Microfluidic System for Dynamic Stimulation and Tracking of Single Cells

with Excellence Grants ranking: ‘Molecular dynamics in hematopoietic stem and progenitor cell fate control’

In vitro biomimetic engineering of a human hematopoietic niche with functional properties

Inductive and Selective Effects of GSK3 and MEK Inhibition on Nanog Heterogeneity in Embryonic Stem Cells

Congratulations Professor Coutu!

Congratulations Dr. Hastreiter!

Congratulations!

in Hinxton, Cambridge UK.

Engineering Human Bone Marrow Proxies

Mouse and human HSPC immobilization in liquid culture by CD43 or CD44-antibody coating

at the Terry Fox Laboratory, BC Cancer Agency, Vancouver, Canada

For research visit in Vancouver, Canada. Congratulations!

Cell Systems Dynamics Group on joint retreat with Basel and Zurich University groups.

Multicolor quantitative confocal imaging cytometry

Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell–mediated TNFα signaling  

Congratulations!

Congratulations!

for Dan, Konstantinos and Leo’s image of the central sinus of mouse bone marrow

Three-dimensional map of nonhematopoietic bone and bone-marrow cells and molecules

As lead PI on group grant ‘Confocal Microscope with spectral detection, FLIM and laser ablation’

As lead PI on group grant ‘Confocal Microscope with spectral detection, FLIM and laser ablation’

about ‘Zurich pioneering spirit for the medicine of the future‘ at the University Medicine Zurich annual event.  

with Fabian Theis and Carsten Marr, Munich Germany, and Laleh Haghverdi, Cambridge UK, for their interdisciplinary work ‘Computational single cell profiling quantifies plasticity during blood stem cell differentiation’

The Human Body: the ultimate frontier of complexity

at annual meeting of the Swiss Stem Cell Network (SSCN) in Lausanne

First prize for best poster presentation of final Amgen students meeting in Cambridge, UK

from the German Stem Cell Network (GSCN) to present at the annual meeting of the International Society for Experimental Hematology (ISEH) in Frankfurt, Germany

from the the International Society for Experimental Hematology (ISEH) and the German Stem Cell Network (GSCN) to present at the annual ISEH meeting in Frankfurt, Germany

from the the International Society for Experimental Hematology (ISEH) and the German Stem Cell Network (GSCN) to present at the annual ISEH meeting in Frankfurt, Germany

to present at the annual meeting of the International Society for Experimental Hematology (ISEH) in Frankfurt, Germany

to present at the annual meeting of the International Society for Experimental Hematology (ISEH) in Frankfurt, Germany

As co-PI in Novartis FreeNovation grant ‘Microfluidic 3D lymph node tissue engineering’ with Matthias Mehling from Basel University

Cell Systems Dynamics Group on joint retreat with Lausanne EPFL’s Radtke, Lutolf, Deplancke, Suter and Naveiras, Basel University’s Martin and Heidelberg DKFZ’s Trumpp and Essers Groups. This year organized by Leo and Tobi.

The image film was produced for the department's 10 year anniversary. 

for Nature paper ‘Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios’

fastER: a user-friendly tool for ultrafast and robust cell segmentation in large-scale microscopy

in Basel, Switzerland

Prospective identification of hematopoietic lineage choice by deep learning

Cell Systems Dynamics Group on joint retreat with Basel and Zurich University groups.

CSF-1-induced Src signaling can instruct monocytic lineage choice

Congratulations - Excellent job! Never disturbed once (but scientific contributions could still improve)

Challenges in long-term imaging and quantification of single-cell dynamics

at Life Sciences PostDoc Day in Zurich

at All SystemsX.ch Day in Bern

of International Society for Experimental Hematology (ISEH).

in San Diego, USA.

to present at the annual meeting of the International Society for Experimental Hematology (ISEH) in San Diego, CA, USA

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios

Software tools for single-cell tracking and quantification of cellular and molecular properties

‘Die Heilkraft der Blutstammzellen’

Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell quantification

at annual meeting of the Swiss Stem Cell Network (SSCN) in Fribourg

Congratulations!

Cell Systems Dynamics Group on joint retreat with Lausanne EPFL’s Radtke, Lutolf, Deplancke, Hülsken, Suter and Naveiras, Basel University’s Martin and Heidelberg DKFZ’s Trumpp and Essers Groups. This year organized by Leo and Nouraiz.

as best student of Biomedical Engineering Master program at ETH Zurich department ITET. Congratulations!

for his research visit in our group from Rice University, USA. Congratulations!

Visitors from the United World College Freiburg, Germany, were from Italy, Hungary, China, Armenia, Germany and Burma.

Cell Systems Dynamics Group on joint retreat with Gottgens, Kent and Laurenti stem cell research groups in Cambridge.

in Hinxton, Cambridge UK.

to Wellcome Genome Campus conference ‘Single Cell Biology’ in Hinxton, UK

to Wellcome Genome Campus conference ‘Single Cell Biology’ in Hinxton, UK

to Wellcome Genome Campus conference ‘Single Cell Biology’ in Hinxton, UK

to Next Gen Immunology 2016 meeting in Rehovot, Israel

Cell Systems Dynamics Group on joint retreat with Basel and Zurich University groups.

Swiss European Mobility Program fellowship. Congratulations!

Congratulations Professor King!

IWMH5 - 5th International Workshop on Humanized Mice in Zurich, Switzerland

for SystemsX Transition Postdoc Fellowship (TPdF). Congratulations!

Network plasticity of pluripotency transcription factors in embryonic stem cells.

to the annual meeting of the International Society for Experimental Hematology (ISEH) in Kyoto, Japan

SystemsX Transition Postdoc Fellowship (TPdF). Congratulations!

Cell Systems Dynamics Group on joint retreat with Lausanne EPFL’s Radtke, Lutolf, Deplancke, Hülsken and Naveiras and Heidelberg DKFZ’s Trumpp and Essers Groups.

by the Kyoto University Foundation. Congratulations!

to the Keystone meeting ‘Hematopoiesis’ in Keystone, Colorado, USA

‘Hematopoiesis’ in Keystone, Colorado, USA.

Cell Systems Dynamics Group on joint retreat with Skoda, Schwaller, Lengerke (Basel University) and Manz, Mueller, Balananov (Zurich University) groups.

in Experimental Cell Research, edited by Timm with Claus Nerlov (UK) and Shinichi Nishikawa (Japan).

As co-PI in a SystemsX MRD group for analyzing ‘A systems medicine approach to hematopoietic stem cell diseases’

Quantitative Single-Cell Approaches to Stem Cell Research

Congratulations Dr. Endele!

Single-cell technologies sharpen up mammalian stem cell research.

For analyzing ‘Transcription factor dynamics in hematopoietic cell fate control’

Congratulations Dr. Löffler!

Congratulations Dr. Kokkaliaris!

Congratulations Dr. Hoppe!

Today 10 years ago Timm started his independent group in Munich, Germany, which is now the ETH BSSE’s Cell Systems Dynamics group

iPhD grant for joint supervision of PhD student Oliver Hilsenbeck

of the International Society for Experimental Hematology (ISEH).

of the Swiss Stem Cell Network

of the journal PLoS Biology

Timm, Laura and Olli at retreat of the ETHZ D-BSSE’s Stelling Group.

Cell Systems Dynamics Group on joint retreat with Lausanne EPFL’s Barrandon, Radtke, Lutolf, Hülsken and Wolfer and Heidelberg DKFZ’s Essers Groups.

Cell Systems Dynamics Group on joint retreat with the ETHZ D-BSSE’s Tay Group.

Cell Systems Dynamics Group on joint retreat with Skoda, Schwaller, Lengerke (Basel University) and Manz, Mueller, Balananov (Zurich University) groups.

Cell Systems Dynamics Group on joint retreat with EPFL’s Barrandon, Radtke, Lutolf, Hülsken and Wolfer groups.

"Quantitative Single Cell Biology in Stem Cell Research" in Munich, Germany

on history and novel developments in single cell imaging

of the Basel Stem Cell Network

SystemsX Transition Postdoc Fellowship (TPdF). Congratulations!

on biallelic Nanog expression in mESCs

EMBO long-term fellowship. Congratulations!

McCullough and Till Award of The Society for Hematology and Stem Cells

at The Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York City, USA

with members of the Chambers (Edinburgh, UK), Wandless (Stanford, USA) and Lee (Berkeley, USA) labs in Marconi, California, USA

at Berkeley University, USA

at the Helmholtz Center München

at the Terry Fox Laboratories Vancouver, Canada

CIHR long-term fellowship. Congratulations!

Neuherberg / Munich, Germany

On long term single cell imaging

by the Helmholtz Center Munich. Congratulations!

Society of Microcirculation and Vascular Biology. Congratulations!

DAAD fellowship. Congratulations!

Congratulations Dr. Hermann!

on hematopoietic stem cell heterogeneity

European consortium on Stem Cell Research and Systems Biology

Congratulations Professor Rieger!

The Society for Hematology and Stem Cells

Hematopoietic lineage instruction by cytokines proven

Congratulations Dr. Eilken!

Existence of hemogenic endothelial cells proven

at the NIH, Bethesda, USA

with Hennighausen (NIH), Rosen (Baylor College of Medicine) and Kopchick (Ohio U) labs on Isobel Island, Virginia, USA

on single cell imaging of mammalian stem cells

at the RIKEN Center for Developmental Biology, Kobe, Japan

from NIH (Bethesda, USA)

International Society of Experimental Hematology for the future annual meetings in Hamburg, Germany and Boston, USA

Institute of Stem Cell Research, Helmholtz Center München

International Society of Stem Cell Research for the future annual meetings in Toronto, Canada and Cairns, Australia

‘Hematopoiesis’ in the Institute of Stem Cell Research, Helmholtz Center München