Human insulin release dynamics of single pancreatic microtissues
New paper in Advanced Biosystems on a microfluidic in-vitro platform to study human insulin release dynamics of single pancreatic-islet microtissues at high temporal resolution.
The article in Advanced Biosystems, resulting from a collaboration with external page InSphero AG, is titled "In Vitro Platform for Studying Human Insulin Release Dynamics of Single Pancreatic Islet Microtissues at High Resolution" and presents a platform including a standardized human pancreatic islet model, developed at InSphero, and a custom-designed microfluidic hanging-drop perifusion system, developed at BEL. This novel platform was used for studying physiologically relevant and compound-modulated dynamic insulin secretion of single islets. The low sample-to-sample variation of the microtissues and the high temporal resolution that can be achieved with the microfluidic platform constitute an important advancement in islet and diabetes research.
external page Advanced Biosystems by Wiley is publishing research into technologies that enhance and harness biological systems, including systems and synthetic biology, advanced therapeutics, and biohybrids and neurotechnology.