Brain Diseases
external pageBrain diseases come in different forms. Infections, trauma, stroke, seizures, and tumors are some of the major categories of brain diseases. We try to contribute to elucidating some of the disease mechanisms as far as the diseases affect electrical activity patterns of neurons or neuronal networks.
Our high-density microelectrode array (HD-MEA) devices allows for querying neuronal network dynamics repetitively at high spatio-temporal resolution. Questions related to neuronal connectivity, spike coding, and plasticity can be addressed in dissociated neuronal cultures or organotypic slices grown on top of our microelectrode array devices.
Using our technology, we are studying the network characteristics of neural disorders, such as schizophrenia, which exhibit disruptions in oscillatory patterns.
Collaborations
Hoffmann-La Roche Ltd., Basel, Switzerland; Friedrich-Miescher Institute, Basel, Switzerland.
Recent publications
S. Ronchi, A. Buccino, G. Prack, S. Kumar, M. Schröter, M. Fiscella, A. Hierlemann, "Electrophysiological phenotype characterization of human iPSC‐derived neuronal cell lines by means of high‐density microelectrode arrays", Advanced Biology 2021, Article 2000223 (DOI: 10.1002/adbi.202000223). external pageOnline
T. Russell, J. Zhang, M. Okoniewski, F. Franke, S. Bichet, A. Hierlemann, "Medullary respiratory circuit is reorganized by a seasonally-induced program in preparation for hibernation", Frontiers in Neuroscience 2019, 13, Article 376 (DOI: 10.3389/fnins.2019.00376). external pageOnline
K. Yonehara, M. Fiscella, A. Drinnenberg, F. Esposti, S. Trenholm, J. Krol, F. Franke, B. Gross-Scherf, A. Kusnyerik, J. Müller, A. Szabo, J. Jüttner, F. Cordoba, A. P. Reddy, J. Németh, Z. Nagy, F. Munier, A. Hierlemann, B. Roska, "Congenital nystagmus gene FRMD7 is necessary for establishing a neuronal circuit asymmetry for direction selectivity", Neuron 2016, 89(1), pp. 177-193 (DOI: 10.1016/j.neuron.2015.11.032). external pageOnline / external pageVideo abstract
W. Gong, J. Senčar, D.J. Bakkum, D. Jäckel, M. Engelene J. Obien, M. Radivojevic, and A. Hierlemann, "Multiple single-unit long-term tracking on organotypic hippocampal slices using high-density microelectrode arrays", Front. Neurosci. 2016, 10:537 (DOI: 10.3389/fnins.2016.00537). external pageOnline