BEL CMOS chip integral part of wire-bundle system for in-vivo measurements
New paper in Science Advances describing massively parallel microwire arrays for in-vivo neural recording includes CMOS high-density microelectrode-array chips developed at BEL.
New paper titled "Massively parallel microwire arrays integrated with CMOS chips for neural recording", which originated from a collaboration of BEL with groups at Stanford University (USA) and the Crick Institute (UK) was published in Science Advances (A. Obaid, M. E. Hanna, Y.-W. Wu, M. Kollo, R. Racz, M. R. Angle, J. Müller, N. Brackbill, W. Wray, F. Franke, E. J. Chichilnisky, A. Hierlemann, J. B. Ding, A. T. Schaefer, N. A. Melosh, Science Advances 2020, 6 (12), Article eaay2789). It includes a new strategy to interface silicon-based chips with three-dimensional microwire arrays, providing the link between rapidly-developing electronics and high density neural interfaces. The system consists of a bundle of microwires mated to large-scale microelectrode arrays. The system features excellent recording performance, demonstrated via single unit and local-field potential recordings in isolated retina and in the motor cortex or striatum of awake moving mice. The modular design enables a variety of microwire types and sizes to be integrated with different types of pixel arrays.
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