Dual-mode HD-MEA published in IEEE "Journal of solid-state circuits"
System and circuitry details of the new dual-mode high-density microelectrode array system published in the IEEE flagship Journal of solid-state circuits.
CMOS microelectrode arrays (MEAs) feature thousands of electrodes at a spatial resolution on the scale of single cells and are, therefore, ideal tools to support neural-network research. Moreover, they offer high spatio-temporal resolution and signal-to-noise ratio (SNR) to capture all features and subcellular-resolution details of neuronal signaling. The paper in the IEEE Journal of Solid-state Circuits, titled "Extracellular recording of entire neural networks using a dual-mode microelectrode array with 19,584 electrodes and high SNR" by X. Yuan et al. includes details of the new dual-mode (DM) MEA, which enables simultaneous (i) full-frame readout from all electrodes and (ii) high-SNR readout from an arbitrarily selectable subset of electrodes. The DM-MEA includes 19,584 electrodes, 19,584 full-frame recording channels with noise levels of 10.4 μVrms in the action potential (AP) frequency band (300 Hz-5 kHz), 246 low-noise recording channels with noise levels of 3.0 μVrms in the AP band and eight stimulation units. The capacity to simultaneously perform full-frame and high-SNR recordings endows the presented DM-MEA with great flexibility for various applications in neuroscience and pharmacology.