Enhancing cellular therapies through rewiring intracellular signaling pathways

Cells have been engineered for therapies mainly in oncology and for organ regeneration. In addition, there is a great potential in treating metabolic diseases and immuno-deficiencies with cell-based therapies. Researchers in the team of Professor Fussenegger now present a method based on Generalized Engineered Activation Regulators which enables precise control of signaling pathways along which signals are being received and processed within the cell in order to trigger specific gene expression.