Botnar Institute of Immune Engineering
The Botnar Institute of Immune Engineering (BIIE) is a newly founded non-profit research organization focused on the advanced study of immunological systems with a mission to improve child and adolescent health through translation-enabling immune engineering.
The scientific foundation of the BIIE and the broader field of Immune Engineering is based on the interaction of three interdisciplinary subdomains: systems immunology, synthetic immunology and computational immunology. As part of the institute, researchers from diverse backgrounds in immunology, bioengineering, systems biology, computational biology and artificial intelligence work together in this unique multidisciplinary environment.

Research Focus
The BIIE operates across three key pillars that integrate seamlessly:
Systems Immunology: This branch delves into the complex interactions among the molecular and cellular elements of the immune system. By understanding how these components work together to perform biological functions and respond to challenges, systems immunology aims to uncover pathways that can be targeted for preventing diseases.
Computational Immunology: Utilizing powerful data analysis tools, computational immunology applies mathematical and statistical models, as well as artificial intelligence to make sense of immunological data. These approaches provide insights that are crucial for the development of effective therapies.
Synthetic Immunology: At the cutting edge of immune engineering, synthetic immunology involves the design and modification of immune system components to both enhance our natural defenses and repurpose them for therapeutic applications. This innovative approach holds promise for breakthroughs in precision diagnostic tools and treatments.
With generous support from Fondation Botnar, a philanthropic foundation dedicated to the wellbeing of young people globally, the BIIE aims to unlock scientific innovations that will improve health outcomes for children and young people worldwide.
ETH Zurich's Department of Biosystems Science and Engineering (D-BSSE) and the BIIE have established a significant long-term strategic partnership that marks a milestone in advancing scientific innovation and translational research. D-BSSE will host BIIE scientists in its state-of-the-art facilities until the institute moves to its newly constructed research center in Allschwil. Extending beyond the D-BSSE hosting the BIIE, this close partnership will also facilitate joint research projects, academic programs, shared infrastructure, and personnel exchanges that strengthen both institutions' capabilities in immune engineering research.
Find more information on the external page Botnar Institute of Immune Engineering (BIIE).