Understanding the different components of immune responses to SARS-CoV-2
The immune response to SARS-CoV-2 depends on different cell types (B and T lymphocytes) and the molecules (antibodies) circulating in the body. A pair of studies led by the group of Sai Reddy in collaboration with colleagues from D-BSSE and various Swiss hospitals, provides a greater understanding of the role of immune cells and antibodies in COVID-19 patients. In both studies, single-cell sequencing and computational approaches were used to understand immunity against SARS-CoV-2.
Both studies were published on the pre-print server bioRxiv:
Ehling, R. A. and colleagues (2021) external page Single-cell sequencing of plasma cells from COVID-19 patients reveals highly expanded clonal lineages produce specific and neutralizing antibodies to SARS-CoV-2. https://doi.org/10.1101/2021.02.12.430940
Bieberich, F. and colleagues (2021) external page A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients. https://doi.org/10.1101/2021.02.12.430907.