Cyberloop: Rapid prototyping of biomolecular controllers

One extremely challenging aspect of synthetic biology involves the design and implementation of engineered genetic circuits into living cells. Researchers from the Control Theory and Systems Biology Lab of Mustafa Khammash now present a hybrid framework called Cyberloop, which interfaces living cells with computer using light actuation and fluorescence measurement, in order to facilitate the rapid testing and optimization of circuit designs before they are built.

Reference to original paper in Nature Communications:

Kumar, S., M. Rullan and M. Khammash (2021) Rapid prototyping and design of cybergenetic single-cell controllers. Nature Communications 12, external page https://doi.org/10.1038/s41467-021-25754-6

Learn about the Control Theory and Systems Biology lab led by Mustafa Khammash.