Exploring T-cell memory in COVID-19 recovered patients
Memory T cells play a key role in long-term immunity. In a study by the Boyman-group, University of Zurich, and Andreas Moor, D-BSSE Systems Physiology lab, researchers explored the characteristics of SARS-CoV-2 specific T cells isolated from convalescent patients for up to one year after infection. Using flow cytometry and single cell RNA sequencing, they track T cell clones over time and find specific signatures on a subset of T cells, which are associated with long-lived memory.
Find the original publication:
Adamo, S., J. Michler, Y. Zurbuchen, C. Cervia, P. Taeschler, M. R. Raeber, S. Baghai Sain, J. Nilsson, A. E. Moor & O. Boyman (2021) Signature of long-lived memory CD8+T cells in acute SARS-CoV-2 infection. Nature, external page https://doi.org/ 10.1038/s41586-021-04280-x
Learn about the Systems Physiology lab led by Andreas Moor.