Microphysiological system to advance adoptive cell therapy
Adoptive cell therapy has emerged as promising cancer treatment in recent years. Despite its advantages, clinical applications of this patient-specific therapy face, however, many challenges. A novel microfluidic platform, developed by the group of Andreas Hierlemann in collaboration with members from Timm Schroeder’s group, helps to improve the process of identifying potent anti-tumour immune cells and their corresponding targets, bridging the gap between in-vitro and in-vivo studies.
Original publication:
Nguyen, O T P, P M Misun, C Lohasz, J Lee, W Wang, T Schroeder, and A Hierlemann (2021) external page An immunocompetent microphysiological system to simultaneously investigate effects of anti-tumour natural killer cells on tumour and cardiac microtissues. Frontiers in Immunology, external page https://doi.org/10.3389/fimmu.2021.781337
Learn about the Bio Engineering Laboratory led by Andreas Hierlemann.