Testing drugs for cardiotoxic properties

Pharmaceutical compounds may have cardiotoxic properties, triggering potentially life-threatening arrhythmias. To investigate the effects of drugs on heart muscle cells derived from human stem cells, researchers around Andreas Hierlemann developed an electrophysiological technique for high-density microelectrode arrays, which enables to record intracellular-like signals. This technique may be routinely used in in vitro platforms for cardiotoxicity screening.

03.10.2022 by Carolin Arndt Foppa

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Enlarged view: Graphical abstract. — Graphical abstract illustrating the new platform: porous Pt-black electrodes, arranged in high-density microelectrode arrays, can be used to record intracellular-like signals of cardiomyocytes at large scale repeatedly over an extended period of time (Source: original publication).

Find original publication in ACS Sensors:

Lee, J, T Gänswein, H Ulusan, V Emmenegger, A M Saguner, F Duru, and A Hierlemann (2022) external pageRepeated and on-demand intracellular recordings of cardiomyocytes derived human-induced pluripotent stem cells. https://doi.org/10.1021/acssensors.2c01678

Learn about the Bio Engineering Laboratory led by Andreas Hierlemann.

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