Universal structures for maximally robust biomolecular networks

To preserve their internal states, living systems often need to fully adapt to disturbances from their environment. This robust perfect adaptation (RPA) is ubiquitous in biology. In PNAS, Ankit Gupta and Mustafa Khammash from the Control Theory and Systems Biology lab characterise the universal internal network structures that control maximal RPA. Understanding these mechanisms is essential for a deeper understanding of biological regulation and for designing novel synthetic regulatory circuits.