New insights into developmental precision
Signaling molecules called morphogens guide the formation of patterns in tissues. Their concentration forms gradients along the tissue to determine cell fate. How this mechanism can be robust towards biological noise and what the role of cell size is in pattern formation has long remained unclear. Using mathematical modelling, Jan Adelmann from the Computational Biology group of Dagmar Iber, shed new light on these two key aspects of developmental biology in his Master’s thesis.
Find original publications:
Adelmann, J A, Vetter, R and D Iber (2023) Patterning precision under non-linear morphogen decay and molecular noise. elife, 12/e84757, external pagehttps://doi.org/10.7554/eLife.84757
This publication was highlighted by external pageNature Computational Science.
Adelmann, J A, Vetter, R and D Iber (2023) Impact of cell size on morphogen gradient precision. Development, external pagehttps://doi.org/10.1242/dev.201702.
This publication was also featured by external pageDevelopment.
Learn about the Computational Biology group led by Dagmar Iber. Jan Adelmann now is a doctoral student in this group, continuting his research on developmental precision.